PFKFB3 activates CAD to enhancede novopyrimidine synthesis for cell growth

Qingen Da; Yongfeng Cai; Qian Ma; Qiuhua Yang; Yapeng Cao; Yaqi Zhou; Dingwei Zhao; Zhiping Liu; Jiean Xu; Junming Quan; Liang Zhang; Rui Wang; Xuejun Jiang; Xiao Liu; Kunfu Ouyang; Zhen Han; Jikui Liu; Tao Wang; Chunxiang Zhang; Neal L. Weintraub; David J.R. Fulton; Jun Zhao; Mei Hong; Zigang Li; Yuqing Huo

doi:10.1016/j.celrep.2026.117318

PFKFB3 activates CAD to enhancede novopyrimidine synthesis for cell growth

Qingen Da
, Yongfeng Cai
, Qian Ma
, Qiuhua Yang
, Yapeng Cao
, Yaqi Zhou
, Dingwei Zhao
, Zhiping Liu
, Jiean Xu
, Junming Quan
, Liang Zhang
, Rui Wang
, Xuejun Jiang
, Xiao Liu
, Kunfu Ouyang
, Zhen Han
, Jikui Liu
, Tao Wang
, Chunxiang Zhang
, Neal L. Weintraub

David J.R. Fulton, Jun Zhao, Mei Hong, Zigang Li, Yuqing Huo

Pharmacological Sciences

Research output: Contribution to journal › Comment/debate

Abstract

(Cell Reports 44, 116071; August 26, 2025) As this paper was originally published on July 29, 2025, the bar graphs in Figures 4G and 4H were identical. This error occurred during figure preparation. The authors reviewed and verified the original data and have provided a revised version of Figure 4, which can be seen below. The paper has also been updated online.

Original language	English
Article number	117318
Journal	Cell Reports
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2026.117318
State	Published - Apr 28 2026

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10.1016/j.celrep.2026.117318

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@article{c66f240f245c47cc966be490373634fc,

title = "PFKFB3 activates CAD to enhancede novopyrimidine synthesis for cell growth",

abstract = "(Cell Reports 44, 116071; August 26, 2025) As this paper was originally published on July 29, 2025, the bar graphs in Figures 4G and 4H were identical. This error occurred during figure preparation. The authors reviewed and verified the original data and have provided a revised version of Figure 4, which can be seen below. The paper has also been updated online.",

author = "Qingen Da and Yongfeng Cai and Qian Ma and Qiuhua Yang and Yapeng Cao and Yaqi Zhou and Dingwei Zhao and Zhiping Liu and Jiean Xu and Junming Quan and Liang Zhang and Rui Wang and Xuejun Jiang and Xiao Liu and Kunfu Ouyang and Zhen Han and Jikui Liu and Tao Wang and Chunxiang Zhang and Weintraub, \{Neal L.\} and Fulton, \{David J.R.\} and Jun Zhao and Mei Hong and Zigang Li and Yuqing Huo",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/",

year = "2026",

month = apr,

day = "28",

doi = "10.1016/j.celrep.2026.117318",

language = "English",

volume = "45",

journal = "Cell Reports",

issn = "2639-1856",

number = "4",

}

Da, Q, Cai, Y, Ma, Q, Yang, Q, Cao, Y, Zhou, Y, Zhao, D, Liu, Z, Xu, J, Quan, J, Zhang, L, Wang, R, Jiang, X, Liu, X, Ouyang, K, Han, Z, Liu, J, Wang, T, Zhang, C, Weintraub, NL, Fulton, DJR, Zhao, J, Hong, M, Li, Z & Huo, Y 2026, 'PFKFB3 activates CAD to enhancede novopyrimidine synthesis for cell growth', Cell Reports, vol. 45, no. 4, 117318. https://doi.org/10.1016/j.celrep.2026.117318

TY - JOUR

T1 - PFKFB3 activates CAD to enhancede novopyrimidine synthesis for cell growth

AU - Da, Qingen

AU - Cai, Yongfeng

AU - Ma, Qian

AU - Yang, Qiuhua

AU - Cao, Yapeng

AU - Zhou, Yaqi

AU - Zhao, Dingwei

AU - Liu, Zhiping

AU - Xu, Jiean

AU - Quan, Junming

AU - Zhang, Liang

AU - Wang, Rui

AU - Jiang, Xuejun

AU - Liu, Xiao

AU - Ouyang, Kunfu

AU - Han, Zhen

AU - Liu, Jikui

AU - Wang, Tao

AU - Zhang, Chunxiang

AU - Weintraub, Neal L.

AU - Fulton, David J.R.

AU - Zhao, Jun

AU - Hong, Mei

AU - Li, Zigang

AU - Huo, Yuqing

PY - 2026/4/28

Y1 - 2026/4/28

N2 - (Cell Reports 44, 116071; August 26, 2025) As this paper was originally published on July 29, 2025, the bar graphs in Figures 4G and 4H were identical. This error occurred during figure preparation. The authors reviewed and verified the original data and have provided a revised version of Figure 4, which can be seen below. The paper has also been updated online.

AB - (Cell Reports 44, 116071; August 26, 2025) As this paper was originally published on July 29, 2025, the bar graphs in Figures 4G and 4H were identical. This error occurred during figure preparation. The authors reviewed and verified the original data and have provided a revised version of Figure 4, which can be seen below. The paper has also been updated online.

UR - https://www.scopus.com/pages/publications/105035683867

U2 - 10.1016/j.celrep.2026.117318

DO - 10.1016/j.celrep.2026.117318

M3 - Comment/debate

C2 - 41989915

AN - SCOPUS:105035683867

SN - 2639-1856

VL - 45

JO - Cell Reports

JF - Cell Reports

IS - 4

M1 - 117318

ER -

PFKFB3 activates CAD to enhancede novopyrimidine synthesis for cell growth

Abstract

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