Phosphatidic acid (PA)-Preferring phospholipase A1 regulates mitochondrial dynamics

Takashi Baba; Yuriko Kashiwagi; Nagisa Arimitsu; Takeshi Kogure; Ayumi Edo; Tomohiro Maruyama; Kazuki Nakao; Hiroki Nakanishi; Makoto Kinoshita; Michael A. Frohman; Akitsugu Yamamoto; Katsuko Tani

doi:10.1074/jbc.M113.531921

Phosphatidic acid (PA)-Preferring phospholipase A1 regulates mitochondrial dynamics

Takashi Baba
, Yuriko Kashiwagi
, Nagisa Arimitsu
, Takeshi Kogure
, Ayumi Edo
, Tomohiro Maruyama
, Kazuki Nakao
, Hiroki Nakanishi
, Makoto Kinoshita
, Michael A. Frohman
, Akitsugu Yamamoto
, Katsuko Tani

Pharmacological Sciences

Tokyo University of Pharmacy and Life Sciences
RIKEN
Akita University
Nagoya University
Nagahama Institute of Bio-Science and Technology

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Background: Phosphatidic acid (PA) is involved in membrane dynamics. Results: PA-preferring phospholipase A1 (PA-PLA1) affects mitochondrial morphology in an activity-dependent manner. Gene disruption of PA-PLA1 in mice causes sperm malformation due to mitochondrial organization defects. Conclusion: PA-PLA1 regulates mitochondrial dynamics. Significance: We demonstrate an in vivo function of PA-PLA1 and suggest a possible mechanism of PA regulation of the mitochondrial membrane.

Original language	English
Pages (from-to)	11497-11511
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	289
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M113.531921
State	Published - Apr 18 2014

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title = "Phosphatidic acid (PA)-Preferring phospholipase A1 regulates mitochondrial dynamics",

abstract = "Background: Phosphatidic acid (PA) is involved in membrane dynamics. Results: PA-preferring phospholipase A1 (PA-PLA1) affects mitochondrial morphology in an activity-dependent manner. Gene disruption of PA-PLA1 in mice causes sperm malformation due to mitochondrial organization defects. Conclusion: PA-PLA1 regulates mitochondrial dynamics. Significance: We demonstrate an in vivo function of PA-PLA1 and suggest a possible mechanism of PA regulation of the mitochondrial membrane.",

author = "Takashi Baba and Yuriko Kashiwagi and Nagisa Arimitsu and Takeshi Kogure and Ayumi Edo and Tomohiro Maruyama and Kazuki Nakao and Hiroki Nakanishi and Makoto Kinoshita and Frohman, \{Michael A.\} and Akitsugu Yamamoto and Katsuko Tani",

year = "2014",

month = apr,

day = "18",

doi = "10.1074/jbc.M113.531921",

language = "English",

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TY - JOUR

T1 - Phosphatidic acid (PA)-Preferring phospholipase A1 regulates mitochondrial dynamics

AU - Baba, Takashi

AU - Kashiwagi, Yuriko

AU - Arimitsu, Nagisa

AU - Kogure, Takeshi

AU - Edo, Ayumi

AU - Maruyama, Tomohiro

AU - Nakao, Kazuki

AU - Nakanishi, Hiroki

AU - Kinoshita, Makoto

AU - Frohman, Michael A.

AU - Yamamoto, Akitsugu

AU - Tani, Katsuko

PY - 2014/4/18

Y1 - 2014/4/18

N2 - Background: Phosphatidic acid (PA) is involved in membrane dynamics. Results: PA-preferring phospholipase A1 (PA-PLA1) affects mitochondrial morphology in an activity-dependent manner. Gene disruption of PA-PLA1 in mice causes sperm malformation due to mitochondrial organization defects. Conclusion: PA-PLA1 regulates mitochondrial dynamics. Significance: We demonstrate an in vivo function of PA-PLA1 and suggest a possible mechanism of PA regulation of the mitochondrial membrane.

AB - Background: Phosphatidic acid (PA) is involved in membrane dynamics. Results: PA-preferring phospholipase A1 (PA-PLA1) affects mitochondrial morphology in an activity-dependent manner. Gene disruption of PA-PLA1 in mice causes sperm malformation due to mitochondrial organization defects. Conclusion: PA-PLA1 regulates mitochondrial dynamics. Significance: We demonstrate an in vivo function of PA-PLA1 and suggest a possible mechanism of PA regulation of the mitochondrial membrane.

UR - https://www.scopus.com/pages/publications/84898995787

U2 - 10.1074/jbc.M113.531921

DO - 10.1074/jbc.M113.531921

M3 - Article

C2 - 24599962

AN - SCOPUS:84898995787

SN - 0021-9258

VL - 289

SP - 11497

EP - 11511

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 16

ER -

Phosphatidic acid (PA)-Preferring phospholipase A1 regulates mitochondrial dynamics

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