Photodynamic therapy-induced microvascular changes in a nonmelanoma skin cancer model assessed by photoacoustic microscopy and diffuse correlation spectroscopy

Daniel J. Rohrbach; Hakeem Salem; Mehmet Aksahin; Ulas Sunar

doi:10.3390/photonics3030048

Photodynamic therapy-induced microvascular changes in a nonmelanoma skin cancer model assessed by photoacoustic microscopy and diffuse correlation spectroscopy

Daniel J. Rohrbach
, Hakeem Salem
, Mehmet Aksahin
, Ulas Sunar

Dept of Biomedical Engineering

Wright State University
Roswell Park Cancer Institute
Baskent University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

One of the main mechanisms of action for photodynamic therapy (PDT) is the destruction of tumor vasculature. We observed the PDT-induced vasculature destruction in a mouse model of skin cancer using two techniques: Photoacoustic microscopy (PAM) and diffuse correlation spectroscopy (DCS). PAM showed high-resolution images of the abnormal microvasculature near the establishing tumor area at pre-PDT, as well as the subsequent destruction of those vessels post-PDT. DCS indicated a significant blood flow decrease after PDT, confirming the vascular destruction. Noninvasive assessment of vascular changes may be indicative of therapy response.

Original language	English
Article number	48
Journal	Photonics
Volume	3
Issue number	3
DOIs	https://doi.org/10.3390/photonics3030048
State	Published - Sep 1 2016

Keywords

Blood flow
Microvasculature
Photoacoustic microscopy
Photodynamic therapy
Skin cancer

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title = "Photodynamic therapy-induced microvascular changes in a nonmelanoma skin cancer model assessed by photoacoustic microscopy and diffuse correlation spectroscopy",

abstract = "One of the main mechanisms of action for photodynamic therapy (PDT) is the destruction of tumor vasculature. We observed the PDT-induced vasculature destruction in a mouse model of skin cancer using two techniques: Photoacoustic microscopy (PAM) and diffuse correlation spectroscopy (DCS). PAM showed high-resolution images of the abnormal microvasculature near the establishing tumor area at pre-PDT, as well as the subsequent destruction of those vessels post-PDT. DCS indicated a significant blood flow decrease after PDT, confirming the vascular destruction. Noninvasive assessment of vascular changes may be indicative of therapy response.",

keywords = "Blood flow, Microvasculature, Photoacoustic microscopy, Photodynamic therapy, Skin cancer",

author = "Rohrbach, \{Daniel J.\} and Hakeem Salem and Mehmet Aksahin and Ulas Sunar",

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doi = "10.3390/photonics3030048",

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T1 - Photodynamic therapy-induced microvascular changes in a nonmelanoma skin cancer model assessed by photoacoustic microscopy and diffuse correlation spectroscopy

AU - Rohrbach, Daniel J.

AU - Salem, Hakeem

AU - Aksahin, Mehmet

AU - Sunar, Ulas

PY - 2016/9/1

Y1 - 2016/9/1

N2 - One of the main mechanisms of action for photodynamic therapy (PDT) is the destruction of tumor vasculature. We observed the PDT-induced vasculature destruction in a mouse model of skin cancer using two techniques: Photoacoustic microscopy (PAM) and diffuse correlation spectroscopy (DCS). PAM showed high-resolution images of the abnormal microvasculature near the establishing tumor area at pre-PDT, as well as the subsequent destruction of those vessels post-PDT. DCS indicated a significant blood flow decrease after PDT, confirming the vascular destruction. Noninvasive assessment of vascular changes may be indicative of therapy response.

AB - One of the main mechanisms of action for photodynamic therapy (PDT) is the destruction of tumor vasculature. We observed the PDT-induced vasculature destruction in a mouse model of skin cancer using two techniques: Photoacoustic microscopy (PAM) and diffuse correlation spectroscopy (DCS). PAM showed high-resolution images of the abnormal microvasculature near the establishing tumor area at pre-PDT, as well as the subsequent destruction of those vessels post-PDT. DCS indicated a significant blood flow decrease after PDT, confirming the vascular destruction. Noninvasive assessment of vascular changes may be indicative of therapy response.

KW - Blood flow

KW - Microvasculature

KW - Photoacoustic microscopy

KW - Photodynamic therapy

KW - Skin cancer

UR - https://www.scopus.com/pages/publications/85013224002

U2 - 10.3390/photonics3030048

DO - 10.3390/photonics3030048

M3 - Article

AN - SCOPUS:85013224002

SN - 2304-6732

VL - 3

JO - Photonics

JF - Photonics

IS - 3

M1 - 48

ER -

Photodynamic therapy-induced microvascular changes in a nonmelanoma skin cancer model assessed by photoacoustic microscopy and diffuse correlation spectroscopy

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