TY - JOUR
T1 - Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
AU - Johnsen, Nina Føns
AU - Tjønneland, Anne
AU - Thomsen, Birthe L.R.
AU - Christensen, Jane
AU - Loft, Steffen
AU - Friedenreich, Christine
AU - Key, Timothy J.
AU - Allen, Naomi E.
AU - Lahmann, Petra H.
AU - Mejlvig, Lotte
AU - Overvad, Kim
AU - Kaaks, Rudolf
AU - Rohrmann, Sabine
AU - Boing, Heiner
AU - Misirli, Gesthimani
AU - Trichopoulou, Antonia
AU - Zylis, Dimosthenis
AU - Tumino, Rosario
AU - Pala, Valeria
AU - Bueno-de-Mesquita, H. Bas
AU - Kiemeney, Lambertus A.
AU - Suárez, Laudina Rodríguez
AU - Gonzalez, Carlos A.
AU - Sánchez, Maria José
AU - Huerta, José María
AU - Gurrea, Aurelio Barricarte
AU - Manjer, Jonas
AU - Wirfält, Elisabet
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Boffetta, Paolo
AU - Egevad, Lars
AU - Rinaldi, Sabina
AU - Riboli, Elio
PY - 2009/8/15
Y1 - 2009/8/15
N2 - The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a metabolic equivalent (MET) score based on weekly time spent on the 4 activities; and a physical activity index. MET hours per week of leisure time activity, higher score in the physical activity index, participation in any of the 4 leisure time activities, and the number of leisure time activities in which the participants were active were not associated with prostate cancer incidence. However, higher level of occupational physical activity was associated with lower risk of advanced stage prostate cancer (ptrend = 0.024). In conclusion, our data support the hypothesis of an inverse association between advanced prostate cancer risk and occupational physical activity, but we found no support for an association between prostate cancer risk and leisure time physical activity.
AB - The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a metabolic equivalent (MET) score based on weekly time spent on the 4 activities; and a physical activity index. MET hours per week of leisure time activity, higher score in the physical activity index, participation in any of the 4 leisure time activities, and the number of leisure time activities in which the participants were active were not associated with prostate cancer incidence. However, higher level of occupational physical activity was associated with lower risk of advanced stage prostate cancer (ptrend = 0.024). In conclusion, our data support the hypothesis of an inverse association between advanced prostate cancer risk and occupational physical activity, but we found no support for an association between prostate cancer risk and leisure time physical activity.
KW - Cohort
KW - Exercise
KW - Physical activity
KW - Prostate cancer
UR - https://www.scopus.com/pages/publications/67650071228
U2 - 10.1002/ijc.24326
DO - 10.1002/ijc.24326
M3 - Article
C2 - 19415749
AN - SCOPUS:67650071228
SN - 0020-7136
VL - 125
SP - 902
EP - 908
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 4
ER -