Platelet-derived growth factor in Dupuytren's disease

Marie A. Badalamente; Lawrence C. Hurst; Shawn K. Grandia; Steven P. Sampson

doi:10.1016/0363-5023(92)90414-K

Platelet-derived growth factor in Dupuytren's disease

Orthopaedics

Stony Brook University

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46 Scopus citations

Abstract

This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.

Original language	English
Pages (from-to)	317-323
Number of pages	7
Journal	Journal of Hand Surgery
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/0363-5023(92)90414-K
State	Published - Mar 1992

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title = "Platelet-derived growth factor in Dupuytren's disease",

abstract = "This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.",

author = "Badalamente, \{Marie A.\} and Hurst, \{Lawrence C.\} and Grandia, \{Shawn K.\} and Sampson, \{Steven P.\}",

year = "1992",

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T1 - Platelet-derived growth factor in Dupuytren's disease

AU - Badalamente, Marie A.

AU - Hurst, Lawrence C.

AU - Grandia, Shawn K.

AU - Sampson, Steven P.

PY - 1992/3

Y1 - 1992/3

N2 - This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.

AB - This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.

UR - https://www.scopus.com/pages/publications/0026550692

U2 - 10.1016/0363-5023(92)90414-K

DO - 10.1016/0363-5023(92)90414-K

M3 - Article

C2 - 1564283

AN - SCOPUS:0026550692

SN - 0363-5023

VL - 17

SP - 317

EP - 323

JO - Journal of Hand Surgery

JF - Journal of Hand Surgery

IS - 2

ER -

Platelet-derived growth factor in Dupuytren's disease

Abstract

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