Platelet procoagulation and DPIV measurements in models of arterial stenosis

Yang H. Yun; Sagi Raz; Ygael Grad; Shmuel Einav; Jolyon Jesty; Danny Bluestein

Platelet procoagulation and DPIV measurements in models of arterial stenosis

Yang H. Yun
, Sagi Raz
, Ygael Grad
, Shmuel Einav
, Jolyon Jesty
, Danny Bluestein

Biomedical Engineering

Stony Brook University

Research output: Contribution to journal › Conference article › peer-review

Abstract

The pathology of arteriosclerosis is associated with thrombus formation, where elevated hemodynamic stresses induce platelet activation and aggregation. In vitro flow and platelet measurements were conducted, aimed at quantifying the flow induced proacogulant properties of the platelets in models of arterial stenosis. Using DPIV (Digital Particle Image Velocimetry), the flow field of various stenosis models was quantified at Re = 300. Concurrently, in vitro platelet studies were conducted with siliconized glass stenosis models mounted in a recirculation loop, by measuring the platelets ability to support the activation of acetylated human prothrombin by factory Xa. The obtained data was analyzed in detail.

Original language	English
Pages (from-to)	S-66-S-67
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
State	Published - 2000
Event	2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA Duration: Oct 12 2000 → Oct 14 2000

Cite this

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title = "Platelet procoagulation and DPIV measurements in models of arterial stenosis",

abstract = "The pathology of arteriosclerosis is associated with thrombus formation, where elevated hemodynamic stresses induce platelet activation and aggregation. In vitro flow and platelet measurements were conducted, aimed at quantifying the flow induced proacogulant properties of the platelets in models of arterial stenosis. Using DPIV (Digital Particle Image Velocimetry), the flow field of various stenosis models was quantified at Re = 300. Concurrently, in vitro platelet studies were conducted with siliconized glass stenosis models mounted in a recirculation loop, by measuring the platelets ability to support the activation of acetylated human prothrombin by factory Xa. The obtained data was analyzed in detail.",

author = "Yun, \{Yang H.\} and Sagi Raz and Ygael Grad and Shmuel Einav and Jolyon Jesty and Danny Bluestein",

year = "2000",

language = "English",

volume = "28",

pages = "S--66--S--67",

journal = "Annals of Biomedical Engineering",

issn = "0090-6964",

number = "SUPPL. 1",

note = "2000 Annual Fall Meeting of the Biomedical Engineering Society ; Conference date: 12-10-2000 Through 14-10-2000",

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TY - JOUR

T1 - Platelet procoagulation and DPIV measurements in models of arterial stenosis

AU - Yun, Yang H.

AU - Raz, Sagi

AU - Grad, Ygael

AU - Einav, Shmuel

AU - Jesty, Jolyon

AU - Bluestein, Danny

PY - 2000

Y1 - 2000

N2 - The pathology of arteriosclerosis is associated with thrombus formation, where elevated hemodynamic stresses induce platelet activation and aggregation. In vitro flow and platelet measurements were conducted, aimed at quantifying the flow induced proacogulant properties of the platelets in models of arterial stenosis. Using DPIV (Digital Particle Image Velocimetry), the flow field of various stenosis models was quantified at Re = 300. Concurrently, in vitro platelet studies were conducted with siliconized glass stenosis models mounted in a recirculation loop, by measuring the platelets ability to support the activation of acetylated human prothrombin by factory Xa. The obtained data was analyzed in detail.

AB - The pathology of arteriosclerosis is associated with thrombus formation, where elevated hemodynamic stresses induce platelet activation and aggregation. In vitro flow and platelet measurements were conducted, aimed at quantifying the flow induced proacogulant properties of the platelets in models of arterial stenosis. Using DPIV (Digital Particle Image Velocimetry), the flow field of various stenosis models was quantified at Re = 300. Concurrently, in vitro platelet studies were conducted with siliconized glass stenosis models mounted in a recirculation loop, by measuring the platelets ability to support the activation of acetylated human prothrombin by factory Xa. The obtained data was analyzed in detail.

UR - https://www.scopus.com/pages/publications/0034513292

M3 - Conference article

AN - SCOPUS:0034513292

SN - 0090-6964

VL - 28

SP - S-66-S-67

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - SUPPL. 1

T2 - 2000 Annual Fall Meeting of the Biomedical Engineering Society

Y2 - 12 October 2000 through 14 October 2000

ER -

Platelet procoagulation and DPIV measurements in models of arterial stenosis

Abstract

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