Polyfunctional Aliphatic Compounds. II.1 The Cyclization of Dinitriles by Anhydrous Halogen Acids. Pyridines

Francis Johnson; J. P. Panella; A. A. Carlson; D. H. Hunneman

doi:10.1021/jo01054a044

Polyfunctional Aliphatic Compounds. II.¹ The Cyclization of Dinitriles by Anhydrous Halogen Acids. Pyridines

Francis Johnson
, J. P. Panella
, A. A. Carlson
, D. H. Hunneman

Pharmacological Sciences

Dow Chemical

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The action of anhydrous hydrogen bromide or iodide on 3-hydroxyglutaronitriles or glutacononitriles leads to 2-amino-6-halopyridines in excellent yield. In conjunction with the facile method for the synthesis of the starting materials, this represents a mode of easy access to previously unavailable simple pyridine derivatives.

Original language	English
Pages (from-to)	2473-2478
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	27
Issue number	7
DOIs	https://doi.org/10.1021/jo01054a044
State	Published - Jul 1 1962

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title = "Polyfunctional Aliphatic Compounds. II.1 The Cyclization of Dinitriles by Anhydrous Halogen Acids. Pyridines",

abstract = "The action of anhydrous hydrogen bromide or iodide on 3-hydroxyglutaronitriles or glutacononitriles leads to 2-amino-6-halopyridines in excellent yield. In conjunction with the facile method for the synthesis of the starting materials, this represents a mode of easy access to previously unavailable simple pyridine derivatives.",

author = "Francis Johnson and Panella, \{J. P.\} and Carlson, \{A. A.\} and Hunneman, \{D. H.\}",

year = "1962",

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doi = "10.1021/jo01054a044",

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volume = "27",

pages = "2473--2478",

journal = "Journal of Organic Chemistry",

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AU - Johnson, Francis

AU - Panella, J. P.

AU - Carlson, A. A.

AU - Hunneman, D. H.

PY - 1962/7/1

Y1 - 1962/7/1

N2 - The action of anhydrous hydrogen bromide or iodide on 3-hydroxyglutaronitriles or glutacononitriles leads to 2-amino-6-halopyridines in excellent yield. In conjunction with the facile method for the synthesis of the starting materials, this represents a mode of easy access to previously unavailable simple pyridine derivatives.

AB - The action of anhydrous hydrogen bromide or iodide on 3-hydroxyglutaronitriles or glutacononitriles leads to 2-amino-6-halopyridines in excellent yield. In conjunction with the facile method for the synthesis of the starting materials, this represents a mode of easy access to previously unavailable simple pyridine derivatives.

UR - https://www.scopus.com/pages/publications/0345454508

U2 - 10.1021/jo01054a044

DO - 10.1021/jo01054a044

M3 - Article

AN - SCOPUS:0345454508

SN - 0022-3263

VL - 27

SP - 2473

EP - 2478

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 7

ER -

Polyfunctional Aliphatic Compounds. II.¹ The Cyclization of Dinitriles by Anhydrous Halogen Acids. Pyridines

Abstract

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