Polyphenol intake and gastric cancer risk: Findings from the stomach cancer pooling project (stop)

Facundo Vitelli-Storelli; Marta Rossi; Claudio Pelucchi; Matteo Rota; Domenico Palli; Monica Ferraroni; Nuno Lunet; Samantha Morais; Lizbeth López-Carrillo; David Georgievich Zaridze; Dmitry Maximovich; María Rubín García; Gemma Castaño-Vinyals; Nuria Aragonés; Manuela Garcia de la Hera; Raúl Ulises Hernández-Ramírez; Eva Negri; Rosella Bonzi; Mary H. Ward; Areti Lagiou; Pagona Lagiou; Malaquías López-Cervantes; Paolo Boffetta; M. Constanza Camargo; Maria Paula Curado; Zuo Feng Zhang; Jesus Vioque; Carlo La Vecchia; Vicente Martín Sánchez

doi:10.3390/cancers12103064

Polyphenol intake and gastric cancer risk: Findings from the stomach cancer pooling project (stop)

Facundo Vitelli-Storelli
, Marta Rossi
, Claudio Pelucchi
, Matteo Rota
, Domenico Palli
, Monica Ferraroni
, Nuno Lunet
, Samantha Morais
, Lizbeth López-Carrillo
, David Georgievich Zaridze
, Dmitry Maximovich
, María Rubín García
, Gemma Castaño-Vinyals
, Nuria Aragonés
, Manuela Garcia de la Hera
, Raúl Ulises Hernández-Ramírez
, Eva Negri
, Rosella Bonzi
, Mary H. Ward
, Areti Lagiou

Pagona Lagiou, Malaquías López-Cervantes, Paolo Boffetta, M. Constanza Camargo, Maria Paula Curado, Zuo Feng Zhang, Jesus Vioque, Carlo La Vecchia, Vicente Martín Sánchez

Family , Population and Preventative Medicine

University of Leon
University of Milan
University of Brescia
Institute for the Study and Prevention of Cancer
University of Porto
Instituto Nacional de Salud Publica
Blokhin Cancer Research Center
CIBER Epidemiología y Salud Pública (CIBERESP)
Hospital del Mar
Pompeu Fabra University
ISGlobal
Public Health Division
Instituto de Investigación Sanitaria y Biomédica de Alicante
Yale University
National Institutes of Health
University of West Attica
National and Kapodistrian University of Athens
Harvard University
Universidad Nacional Autónoma de México
A.C.Camargo Cancer Center
University of California at Los Angeles

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95% confidence intervals (95% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95% CI = 0.54–0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95% CI = 0.55–0.90), anthocyanidins (OR = 0.74, 95% CI = 0.56–0.92), flavanols (OR = 0.77, 95% CI = 0.66–0.88), flavanones (OR = 0.57, 95%CI = 0.44–0.69), total phenolic acids (OR = 0.75, 95%CI = 0.55–0.94), and hydroxybenzoic acids (OR = 0.73, 95%CI = 0.57–0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95%CI = 0.51–1.01) and hydroxycinnamic acids (OR = 0.82, 95%CI = 0.58–1.06). Further investigations from longitudinal data are needed to confirm this association.

Original language	English
Article number	3064
Pages (from-to)	1-12
Number of pages	12
Journal	Cancers
Volume	12
Issue number	10
DOIs	https://doi.org/10.3390/cancers12103064
State	Published - Oct 2020

Keywords

Diet
Epidemiology
Flavonoids
Gastric cancer
Polyphenols

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10.3390/cancers12103064

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Vitelli-Storelli, F., Rossi, M., Pelucchi, C., Rota, M., Palli, D., Ferraroni, M., Lunet, N., Morais, S., López-Carrillo, L., Zaridze, D. G., Maximovich, D., García, M. R., Castaño-Vinyals, G., Aragonés, N., de la Hera, M. G., Hernández-Ramírez, R. U., Negri, E., Bonzi, R., Ward, M. H., ... Sánchez, V. M. (2020). Polyphenol intake and gastric cancer risk: Findings from the stomach cancer pooling project (stop). Cancers, 12(10), 1-12. Article 3064. https://doi.org/10.3390/cancers12103064

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title = "Polyphenol intake and gastric cancer risk: Findings from the stomach cancer pooling project (stop)",

abstract = "Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95\% confidence intervals (95\% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95\% CI = 0.54–0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95\% CI = 0.55–0.90), anthocyanidins (OR = 0.74, 95\% CI = 0.56–0.92), flavanols (OR = 0.77, 95\% CI = 0.66–0.88), flavanones (OR = 0.57, 95\%CI = 0.44–0.69), total phenolic acids (OR = 0.75, 95\%CI = 0.55–0.94), and hydroxybenzoic acids (OR = 0.73, 95\%CI = 0.57–0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95\%CI = 0.51–1.01) and hydroxycinnamic acids (OR = 0.82, 95\%CI = 0.58–1.06). Further investigations from longitudinal data are needed to confirm this association.",

keywords = "Diet, Epidemiology, Flavonoids, Gastric cancer, Polyphenols",

author = "Facundo Vitelli-Storelli and Marta Rossi and Claudio Pelucchi and Matteo Rota and Domenico Palli and Monica Ferraroni and Nuno Lunet and Samantha Morais and Lizbeth L{\'o}pez-Carrillo and Zaridze, \{David Georgievich\} and Dmitry Maximovich and Garc{\'i}a, \{Mar{\'i}a Rub{\'i}n\} and Gemma Casta{\~n}o-Vinyals and Nuria Aragon{\'e}s and \{de la Hera\}, \{Manuela Garcia\} and Hern{\'a}ndez-Ram{\'i}rez, \{Ra{\'u}l Ulises\} and Eva Negri and Rosella Bonzi and Ward, \{Mary H.\} and Areti Lagiou and Pagona Lagiou and Malaqu{\'i}as L{\'o}pez-Cervantes and Paolo Boffetta and \{Constanza Camargo\}, M. and Curado, \{Maria Paula\} and Zhang, \{Zuo Feng\} and Jesus Vioque and \{La Vecchia\}, Carlo and S{\'a}nchez, \{Vicente Mart{\'i}n\}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = oct,

doi = "10.3390/cancers12103064",

language = "English",

volume = "12",

pages = "1--12",

journal = "Cancers",

issn = "2072-6694",

number = "10",

}

Vitelli-Storelli, F, Rossi, M, Pelucchi, C, Rota, M, Palli, D, Ferraroni, M, Lunet, N, Morais, S, López-Carrillo, L, Zaridze, DG, Maximovich, D, García, MR, Castaño-Vinyals, G, Aragonés, N, de la Hera, MG, Hernández-Ramírez, RU, Negri, E, Bonzi, R, Ward, MH, Lagiou, A, Lagiou, P, López-Cervantes, M, Boffetta, P, Constanza Camargo, M, Curado, MP, Zhang, ZF, Vioque, J, La Vecchia, C & Sánchez, VM 2020, 'Polyphenol intake and gastric cancer risk: Findings from the stomach cancer pooling project (stop)', Cancers, vol. 12, no. 10, 3064, pp. 1-12. https://doi.org/10.3390/cancers12103064

TY - JOUR

T1 - Polyphenol intake and gastric cancer risk

T2 - Findings from the stomach cancer pooling project (stop)

AU - Vitelli-Storelli, Facundo

AU - Rossi, Marta

AU - Pelucchi, Claudio

AU - Rota, Matteo

AU - Palli, Domenico

AU - Ferraroni, Monica

AU - Lunet, Nuno

AU - Morais, Samantha

AU - López-Carrillo, Lizbeth

AU - Zaridze, David Georgievich

AU - Maximovich, Dmitry

AU - García, María Rubín

AU - Castaño-Vinyals, Gemma

AU - Aragonés, Nuria

AU - de la Hera, Manuela Garcia

AU - Hernández-Ramírez, Raúl Ulises

AU - Negri, Eva

AU - Bonzi, Rosella

AU - Ward, Mary H.

AU - Lagiou, Areti

AU - Lagiou, Pagona

AU - López-Cervantes, Malaquías

AU - Boffetta, Paolo

AU - Constanza Camargo, M.

AU - Curado, Maria Paula

AU - Zhang, Zuo Feng

AU - Vioque, Jesus

AU - La Vecchia, Carlo

AU - Sánchez, Vicente Martín

PY - 2020/10

Y1 - 2020/10

N2 - Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95% confidence intervals (95% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95% CI = 0.54–0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95% CI = 0.55–0.90), anthocyanidins (OR = 0.74, 95% CI = 0.56–0.92), flavanols (OR = 0.77, 95% CI = 0.66–0.88), flavanones (OR = 0.57, 95%CI = 0.44–0.69), total phenolic acids (OR = 0.75, 95%CI = 0.55–0.94), and hydroxybenzoic acids (OR = 0.73, 95%CI = 0.57–0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95%CI = 0.51–1.01) and hydroxycinnamic acids (OR = 0.82, 95%CI = 0.58–1.06). Further investigations from longitudinal data are needed to confirm this association.

AB - Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95% confidence intervals (95% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95% CI = 0.54–0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95% CI = 0.55–0.90), anthocyanidins (OR = 0.74, 95% CI = 0.56–0.92), flavanols (OR = 0.77, 95% CI = 0.66–0.88), flavanones (OR = 0.57, 95%CI = 0.44–0.69), total phenolic acids (OR = 0.75, 95%CI = 0.55–0.94), and hydroxybenzoic acids (OR = 0.73, 95%CI = 0.57–0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95%CI = 0.51–1.01) and hydroxycinnamic acids (OR = 0.82, 95%CI = 0.58–1.06). Further investigations from longitudinal data are needed to confirm this association.

KW - Diet

KW - Epidemiology

KW - Flavonoids

KW - Gastric cancer

KW - Polyphenols

UR - https://www.scopus.com/pages/publications/85093660472

U2 - 10.3390/cancers12103064

DO - 10.3390/cancers12103064

M3 - Article

AN - SCOPUS:85093660472

SN - 2072-6694

VL - 12

SP - 1

EP - 12

JO - Cancers

JF - Cancers

IS - 10

M1 - 3064

ER -

Polyphenol intake and gastric cancer risk: Findings from the stomach cancer pooling project (stop)

Abstract

Keywords

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