TY - GEN
T1 - Potential mitigation of the skeletal complications of Duchenne's muscular dystrophy with vibration
AU - Lee, B. J.
AU - Judex, S.
AU - Luu, K.
AU - Thomas, J.
AU - Gilsanz, V.
AU - Rubin, C.
PY - 2007
Y1 - 2007
N2 - A mouse model (mdx) for Duchenne's muscular dystrophy (DMD)1 was used to evaluate the ability of a unique mechanical stimulus, low magnitude, high frequency, mechanical signal (LMMS), to ameliorate the skeletal consequences of DMD. The skeleton of the mdx deviates from the wild type (wt) by 8 wks of age. LMMS did not aggravate the sarcopenia in these mice, and showed a trend in producing an anabolic response in the mdx strain in comparison to the age-matched control as seen in the 64% increase in double labeled surface. In vivo CT scans of the calf muscle were able to determine the hypertrophy in the mdx mice, which is a characteristic of DMD, but not the regions of degeneration. LMMS looks to be a potential treatment for the skeletal pathology of DMD without accelerating the muscle degradation.
AB - A mouse model (mdx) for Duchenne's muscular dystrophy (DMD)1 was used to evaluate the ability of a unique mechanical stimulus, low magnitude, high frequency, mechanical signal (LMMS), to ameliorate the skeletal consequences of DMD. The skeleton of the mdx deviates from the wild type (wt) by 8 wks of age. LMMS did not aggravate the sarcopenia in these mice, and showed a trend in producing an anabolic response in the mdx strain in comparison to the age-matched control as seen in the 64% increase in double labeled surface. In vivo CT scans of the calf muscle were able to determine the hypertrophy in the mdx mice, which is a characteristic of DMD, but not the regions of degeneration. LMMS looks to be a potential treatment for the skeletal pathology of DMD without accelerating the muscle degradation.
UR - https://www.scopus.com/pages/publications/48749093969
U2 - 10.1109/NEBC.2007.4413267
DO - 10.1109/NEBC.2007.4413267
M3 - Conference contribution
AN - SCOPUS:48749093969
SN - 1424410339
SN - 9781424410330
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
SP - 35
EP - 36
BT - 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd Annual Northeast Bioengineering Conference, NEBC
Y2 - 10 March 2007 through 11 March 2007
ER -