Potential roles of fungal extracellular vesicles during infection

Luna S. Joffe; Leonardo Nimrichter; Marcio L. Rodrigues; Maurizio Del Poeta

doi:10.1128/mSphere.00099-16

Potential roles of fungal extracellular vesicles during infection

Luna S. Joffe
, Leonardo Nimrichter
, Marcio L. Rodrigues
, Maurizio Del Poeta

Microbiology and Immunology

Universidade Federal do Rio de Janeiro
Stony Brook University
Fundação Oswaldo Cruz

Research output: Contribution to journal › Short survey › peer-review

105 Scopus citations

Abstract

Extracellular vesicles (EVs) are produced by virtually all cell types. Within the past few years, work in this field has revealed more information about fungal EVs. Fungal EVs have been shown to carry proteins, lipids, pigments, polysaccharides, and RNA; these components are known virulence factors, a fact which supports the hypothesis that fungal EVs concentrate pathogenic determinants. Additionally, recent studies have demonstrated that fungal EVs stimulate the host immune system. In this review, putative roles of fungal EVs are discussed, including their potential as vaccination tools and their possible contribution to pathogenesis in invasive fungal diseases.

Original language	English
Article number	e00099-16
Journal	mSphere
Volume	1
Issue number	4
DOIs	https://doi.org/10.1128/mSphere.00099-16
State	Published - Jul 1 2016

Keywords

Ceramide
Fungal pathogenesis
Fungi
Glycolipids
Sphingolipids
Vesicles

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10.1128/mSphere.00099-16

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title = "Potential roles of fungal extracellular vesicles during infection",

abstract = "Extracellular vesicles (EVs) are produced by virtually all cell types. Within the past few years, work in this field has revealed more information about fungal EVs. Fungal EVs have been shown to carry proteins, lipids, pigments, polysaccharides, and RNA; these components are known virulence factors, a fact which supports the hypothesis that fungal EVs concentrate pathogenic determinants. Additionally, recent studies have demonstrated that fungal EVs stimulate the host immune system. In this review, putative roles of fungal EVs are discussed, including their potential as vaccination tools and their possible contribution to pathogenesis in invasive fungal diseases.",

keywords = "Ceramide, Fungal pathogenesis, Fungi, Glycolipids, Sphingolipids, Vesicles",

author = "Joffe, \{Luna S.\} and Leonardo Nimrichter and Rodrigues, \{Marcio L.\} and \{Del Poeta\}, Maurizio",

note = "Publisher Copyright: {\textcopyright} 2016 Joffe et al.",

year = "2016",

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doi = "10.1128/mSphere.00099-16",

language = "English",

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TY - JOUR

T1 - Potential roles of fungal extracellular vesicles during infection

AU - Joffe, Luna S.

AU - Nimrichter, Leonardo

AU - Rodrigues, Marcio L.

AU - Del Poeta, Maurizio

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Extracellular vesicles (EVs) are produced by virtually all cell types. Within the past few years, work in this field has revealed more information about fungal EVs. Fungal EVs have been shown to carry proteins, lipids, pigments, polysaccharides, and RNA; these components are known virulence factors, a fact which supports the hypothesis that fungal EVs concentrate pathogenic determinants. Additionally, recent studies have demonstrated that fungal EVs stimulate the host immune system. In this review, putative roles of fungal EVs are discussed, including their potential as vaccination tools and their possible contribution to pathogenesis in invasive fungal diseases.

AB - Extracellular vesicles (EVs) are produced by virtually all cell types. Within the past few years, work in this field has revealed more information about fungal EVs. Fungal EVs have been shown to carry proteins, lipids, pigments, polysaccharides, and RNA; these components are known virulence factors, a fact which supports the hypothesis that fungal EVs concentrate pathogenic determinants. Additionally, recent studies have demonstrated that fungal EVs stimulate the host immune system. In this review, putative roles of fungal EVs are discussed, including their potential as vaccination tools and their possible contribution to pathogenesis in invasive fungal diseases.

KW - Ceramide

KW - Fungal pathogenesis

KW - Fungi

KW - Glycolipids

KW - Sphingolipids

KW - Vesicles

UR - https://www.scopus.com/pages/publications/85008380365

U2 - 10.1128/mSphere.00099-16

DO - 10.1128/mSphere.00099-16

M3 - Short survey

AN - SCOPUS:85008380365

SN - 2379-5042

VL - 1

JO - mSphere

JF - mSphere

IS - 4

M1 - e00099-16

ER -

Potential roles of fungal extracellular vesicles during infection

Abstract

Keywords

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