Potentiation of LSD-induced stimulus control by fluoxetine in the rat

David Fiorella; Scott Helsley; Richard A. Rabin; J. C. Winter

doi:10.1016/0024-3205(96)00490-0

Potentiation of LSD-induced stimulus control by fluoxetine in the rat

David Fiorella
, Scott Helsley
, Richard A. Rabin
, J. C. Winter

Surgery

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was shifted to the left. However, stastical significance was observed only for the (+)-enantiomer. It is concluded that the effects of LSD as a discriminative stimulus are potentiated by the acute administration of fluoxetine. These results are consistent with anecdotal reports of interactions between LSD and acutely administered SSRIs in humans.

Original language	English
Pages (from-to)	PL283-PL287
Journal	Life Sciences
Volume	59
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(96)00490-0
State	Published - Sep 27 1996

Keywords

(+)-fluoxetine
(-)-fluoxetine
5-HT(1A) receptors
5-HT receptors
drug-induced stimulus control
hallucinogen
LSD
selective serotonin reuptake inhibitor

Access to Document

10.1016/0024-3205(96)00490-0

Cite this

@article{f45d825599c341c99c89407fc9c2b38b,

title = "Potentiation of LSD-induced stimulus control by fluoxetine in the rat",

abstract = "The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was shifted to the left. However, stastical significance was observed only for the (+)-enantiomer. It is concluded that the effects of LSD as a discriminative stimulus are potentiated by the acute administration of fluoxetine. These results are consistent with anecdotal reports of interactions between LSD and acutely administered SSRIs in humans.",

keywords = "(+)-fluoxetine, (-)-fluoxetine, 5-HT(1A) receptors, 5-HT receptors, drug-induced stimulus control, hallucinogen, LSD, selective serotonin reuptake inhibitor",

author = "David Fiorella and Scott Helsley and Rabin, \{Richard A.\} and Winter, \{J. C.\}",

year = "1996",

month = sep,

day = "27",

doi = "10.1016/0024-3205(96)00490-0",

language = "English",

volume = "59",

pages = "PL283--PL287",

journal = "Life Sciences",

issn = "0024-3205",

number = "18",

}

TY - JOUR

T1 - Potentiation of LSD-induced stimulus control by fluoxetine in the rat

AU - Fiorella, David

AU - Helsley, Scott

AU - Rabin, Richard A.

AU - Winter, J. C.

PY - 1996/9/27

Y1 - 1996/9/27

N2 - The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was shifted to the left. However, stastical significance was observed only for the (+)-enantiomer. It is concluded that the effects of LSD as a discriminative stimulus are potentiated by the acute administration of fluoxetine. These results are consistent with anecdotal reports of interactions between LSD and acutely administered SSRIs in humans.

AB - The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was shifted to the left. However, stastical significance was observed only for the (+)-enantiomer. It is concluded that the effects of LSD as a discriminative stimulus are potentiated by the acute administration of fluoxetine. These results are consistent with anecdotal reports of interactions between LSD and acutely administered SSRIs in humans.

KW - (+)-fluoxetine

KW - (-)-fluoxetine

KW - 5-HT(1A) receptors

KW - 5-HT receptors

KW - drug-induced stimulus control

KW - hallucinogen

KW - LSD

KW - selective serotonin reuptake inhibitor

UR - https://www.scopus.com/pages/publications/16044371912

U2 - 10.1016/0024-3205(96)00490-0

DO - 10.1016/0024-3205(96)00490-0

M3 - Article

C2 - 8890940

AN - SCOPUS:16044371912

SN - 0024-3205

VL - 59

SP - PL283-PL287

JO - Life Sciences

JF - Life Sciences

IS - 18

ER -

Potentiation of LSD-induced stimulus control by fluoxetine in the rat

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this