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Preparation and biological characterization of electrospun aligned poly(butylene carbonate) nano-fibers

  • Donghua University
  • Tongji University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A novel biomaterial poly(butylene carbonate) (PBC) was used to fabricate aligned nano-fibresby electrospinning with a high-speed transfer roller as the receiving device. The morphology of the fibers was evaluated by scanning electron microscopy (SEM). To expand the application of the biomaterial, cold plasma treatment and induced grafting technology were applied to improve its hydrophilicity and biocompatibility. The properties of the fibers, pretreated withhelium and following grafting with gelatin,were evaluated with X-ray photoelectron spectroscopy. The cytotoxicity of the materials to Schwann cells(RSC96) was investigated. Results indicated that aligned nano-fibers can be received at high rotation speed.After plasma pretreatment, the activity of the surface was improved significantly and the grafting reaction was successful. SEM observations showed that cells can grow on the fibersurface along the direction of fiberorientation after seeding with RSC96 for 3 and 5 days. Modification of the nano-fibersurface with gelatin significantly increased RSC96 attachment and proliferation.

Original languageEnglish
Title of host publicationNano-Scale Materials, Materials Processing and Genomic Engineering
PublisherTrans Tech Publications Ltd
Pages122-129
Number of pages8
ISBN (Print)9783038350897
DOIs
StatePublished - 2014
Event12th IUMRS International Conference on Advanced Materials, IUMRS-ICAM 2013 - Qingdao, China
Duration: Sep 22 2013Sep 28 2013

Publication series

NameMaterials Science Forum
Volume789
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Conference

Conference12th IUMRS International Conference on Advanced Materials, IUMRS-ICAM 2013
Country/TerritoryChina
CityQingdao
Period09/22/1309/28/13

Keywords

  • Aligned nano-fibers
  • Cold plasma treatment
  • Cytocompatibility
  • Electrospinning
  • Poly(butylene carbonate)
  • Surface grafting

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