prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

Miriam J. Smyth; David K. Perry; Jiandi Zhang; Guy G. Poirier; Yusuf A. Hannun; Lina M. Obeid

doi:10.1042/bj3160025

prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

Miriam J. Smyth
, David K. Perry
, Jiandi Zhang
, Guy G. Poirier
, Yusuf A. Hannun
, Lina M. Obeid

Cancer Center

Duke University
Durham VA Medical Center
Centre Hospitalier Universitaire de Quebec

Research output: Contribution to journal › Article › peer-review

201 Scopus citations

Abstract

The novel lipid second messenger, ceramide, specifically induced poly(ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bcl-2 protects from cell death.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Biochemical Journal
Volume	316
Issue number	1
DOIs	https://doi.org/10.1042/bj3160025
State	Published - May 15 1996

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title = "prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2",

abstract = "The novel lipid second messenger, ceramide, specifically induced poly(ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bcl-2 protects from cell death.",

author = "Smyth, \{Miriam J.\} and Perry, \{David K.\} and Jiandi Zhang and Poirier, \{Guy G.\} and Hannun, \{Yusuf A.\} and Obeid, \{Lina M.\}",

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doi = "10.1042/bj3160025",

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T2 - A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

AU - Smyth, Miriam J.

AU - Perry, David K.

AU - Zhang, Jiandi

AU - Poirier, Guy G.

AU - Hannun, Yusuf A.

AU - Obeid, Lina M.

PY - 1996/5/15

Y1 - 1996/5/15

N2 - The novel lipid second messenger, ceramide, specifically induced poly(ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bcl-2 protects from cell death.

AB - The novel lipid second messenger, ceramide, specifically induced poly(ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bcl-2 protects from cell death.

UR - https://www.scopus.com/pages/publications/0029949938

U2 - 10.1042/bj3160025

DO - 10.1042/bj3160025

M3 - Article

C2 - 8645213

AN - SCOPUS:0029949938

SN - 0264-6021

VL - 316

SP - 25

EP - 28

JO - Biochemical Journal

JF - Biochemical Journal

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ER -

prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

Abstract

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