Probing conformational dynamics to understand kinase inhibition

Ian R. Outhwaite; Markus A. Seeliger

doi:10.7554/eLife.92753

Probing conformational dynamics to understand kinase inhibition

Ian R. Outhwaite
, Markus A. Seeliger

Stony Brook University

Research output: Contribution to journal › Editorial

4 Scopus citations

Abstract

Why

Original language	English
Journal	eLife
Volume	12
DOIs	https://doi.org/10.7554/eLife.92753
State	Published - Oct 18 2023

Keywords

ERK2
MAP kinase
NMR
allosteric regulation
biochemistry
chemical biology
hydrogen-deuterium exchange mass spectrometry
inhibitor
none

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10.7554/eLife.92753

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title = "Probing conformational dynamics to understand kinase inhibition",

abstract = "Why",

keywords = "ERK2, MAP kinase, NMR, allosteric regulation, biochemistry, chemical biology, hydrogen-deuterium exchange mass spectrometry, inhibitor, none",

author = "Outhwaite, \{Ian R.\} and Seeliger, \{Markus A.\}",

note = "Publisher Copyright: {\textcopyright} 2023, Outhwaite and Seeliger.",

year = "2023",

month = oct,

day = "18",

doi = "10.7554/eLife.92753",

language = "English",

volume = "12",

journal = "eLife",

issn = "2050-084X",

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TY - JOUR

T1 - Probing conformational dynamics to understand kinase inhibition

AU - Outhwaite, Ian R.

AU - Seeliger, Markus A.

PY - 2023/10/18

Y1 - 2023/10/18

N2 - Why

AB - Why

KW - ERK2

KW - MAP kinase

KW - NMR

KW - allosteric regulation

KW - biochemistry

KW - chemical biology

KW - hydrogen-deuterium exchange mass spectrometry

KW - inhibitor

KW - none

UR - https://www.scopus.com/pages/publications/85174641811

U2 - 10.7554/eLife.92753

DO - 10.7554/eLife.92753

M3 - Editorial

C2 - 37850630

AN - SCOPUS:85174641811

SN - 2050-084X

VL - 12

JO - eLife

JF - eLife

ER -

Probing conformational dynamics to understand kinase inhibition

Abstract

Keywords

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