Proximal Tubular Transcription Factors in Acute Kidney Injury: Recent Advances

Sian E. Piret; Sandeep K. Mallipattu

doi:10.1159/000508856

Proximal Tubular Transcription Factors in Acute Kidney Injury: Recent Advances

Nephrology and Hypertension

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The proximal tubule (PT) is a major target in acute kidney injury (AKI), leading to profound changes in PT cell biology. Amongst the genes with early and robust changes in expression are many transcription factors (TFs), which themselves account for other transcriptomic changes. Potentially important TFs are being revealed in large sequencing datasets; however, to understand whether these TFs account for adaptive or maladaptive changes requires further mechanistic studies, which may reveal novel therapeutic targets. This mini review will highlight the identification and biology of 3 novel TFs in AKI: Sox9, Foxm1, and Foxo3.

Original language	English
Pages (from-to)	613-615
Number of pages	3
Journal	Nephron
Volume	144
Issue number	12
DOIs	https://doi.org/10.1159/000508856
State	Published - Dec 2020

Keywords

Acute kidney injury
Proximal tubule
RNA sequencing
Transcription factors

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10.1159/000508856

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title = "Proximal Tubular Transcription Factors in Acute Kidney Injury: Recent Advances",

abstract = "The proximal tubule (PT) is a major target in acute kidney injury (AKI), leading to profound changes in PT cell biology. Amongst the genes with early and robust changes in expression are many transcription factors (TFs), which themselves account for other transcriptomic changes. Potentially important TFs are being revealed in large sequencing datasets; however, to understand whether these TFs account for adaptive or maladaptive changes requires further mechanistic studies, which may reveal novel therapeutic targets. This mini review will highlight the identification and biology of 3 novel TFs in AKI: Sox9, Foxm1, and Foxo3.",

keywords = "Acute kidney injury, Proximal tubule, RNA sequencing, Transcription factors",

author = "Piret, \{Sian E.\} and Mallipattu, \{Sandeep K.\}",

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year = "2020",

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N2 - The proximal tubule (PT) is a major target in acute kidney injury (AKI), leading to profound changes in PT cell biology. Amongst the genes with early and robust changes in expression are many transcription factors (TFs), which themselves account for other transcriptomic changes. Potentially important TFs are being revealed in large sequencing datasets; however, to understand whether these TFs account for adaptive or maladaptive changes requires further mechanistic studies, which may reveal novel therapeutic targets. This mini review will highlight the identification and biology of 3 novel TFs in AKI: Sox9, Foxm1, and Foxo3.

AB - The proximal tubule (PT) is a major target in acute kidney injury (AKI), leading to profound changes in PT cell biology. Amongst the genes with early and robust changes in expression are many transcription factors (TFs), which themselves account for other transcriptomic changes. Potentially important TFs are being revealed in large sequencing datasets; however, to understand whether these TFs account for adaptive or maladaptive changes requires further mechanistic studies, which may reveal novel therapeutic targets. This mini review will highlight the identification and biology of 3 novel TFs in AKI: Sox9, Foxm1, and Foxo3.

KW - Acute kidney injury

KW - Proximal tubule

KW - RNA sequencing

KW - Transcription factors

UR - https://www.scopus.com/pages/publications/85088361330

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IS - 12

ER -

Proximal Tubular Transcription Factors in Acute Kidney Injury: Recent Advances

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Keywords

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