Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy

Congwu Du; Hanli Liu; Britton Chance

Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy

Congwu Du
, Hanli Liu
, Britton Chance

Dept of Biomedical Engineering

University of Pennsylvania

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Int his article, we analytically present the influence of the systematic error due to the theoretical assumptions on the blood oxygenation determination using a 'phase-only' dual-wavelength phase-modulation spectroscopy (PMS). To approach an accurate quantification of hemoglobin saturation, an empirical method to experimentally acquire the initial phase-shift value in oxygenation quantification form PMS data is investigated on blood-perfused phantom. Our results show that the quantification error of blood oxygenation determination can be substantially compensated by using the acquired θ ₀ ^λ method and is confirmed to be less than 10 percent by comparison with the measured results of the Pt electrode.

Original language	English
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	David A. Benaron, Britton Chance, Gerhard J. Mueller
Pages	189-198
Number of pages	10
Volume	2925
State	Published - 1996
Event	Photon Propagation in Tissues II - Vienna, Austria Duration: Sep 7 1996 → Sep 8 1996

Conference

Conference	Photon Propagation in Tissues II
City	Vienna, Austria
Period	09/7/96 → 09/8/96

Cite this

@inproceedings{b2ed22265348414799669e86032eedbb,

title = "Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy",

abstract = "Int his article, we analytically present the influence of the systematic error due to the theoretical assumptions on the blood oxygenation determination using a 'phase-only' dual-wavelength phase-modulation spectroscopy (PMS). To approach an accurate quantification of hemoglobin saturation, an empirical method to experimentally acquire the initial phase-shift value in oxygenation quantification form PMS data is investigated on blood-perfused phantom. Our results show that the quantification error of blood oxygenation determination can be substantially compensated by using the acquired θ 0 λ method and is confirmed to be less than 10 percent by comparison with the measured results of the Pt electrode.",

author = "Congwu Du and Hanli Liu and Britton Chance",

year = "1996",

language = "English",

isbn = "0819423270",

volume = "2925",

pages = "189--198",

editor = "Benaron, \{David A.\} and Britton Chance and Mueller, \{Gerhard J.\}",

booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

note = "Photon Propagation in Tissues II ; Conference date: 07-09-1996 Through 08-09-1996",

}

Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy. / Du, Congwu; Liu, Hanli; Chance, Britton.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / David A. Benaron; Britton Chance; Gerhard J. Mueller. Vol. 2925 1996. p. 189-198.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy

AU - Du, Congwu

AU - Liu, Hanli

AU - Chance, Britton

PY - 1996

Y1 - 1996

N2 - Int his article, we analytically present the influence of the systematic error due to the theoretical assumptions on the blood oxygenation determination using a 'phase-only' dual-wavelength phase-modulation spectroscopy (PMS). To approach an accurate quantification of hemoglobin saturation, an empirical method to experimentally acquire the initial phase-shift value in oxygenation quantification form PMS data is investigated on blood-perfused phantom. Our results show that the quantification error of blood oxygenation determination can be substantially compensated by using the acquired θ 0 λ method and is confirmed to be less than 10 percent by comparison with the measured results of the Pt electrode.

AB - Int his article, we analytically present the influence of the systematic error due to the theoretical assumptions on the blood oxygenation determination using a 'phase-only' dual-wavelength phase-modulation spectroscopy (PMS). To approach an accurate quantification of hemoglobin saturation, an empirical method to experimentally acquire the initial phase-shift value in oxygenation quantification form PMS data is investigated on blood-perfused phantom. Our results show that the quantification error of blood oxygenation determination can be substantially compensated by using the acquired θ 0 λ method and is confirmed to be less than 10 percent by comparison with the measured results of the Pt electrode.

UR - https://www.scopus.com/pages/publications/0030370731

M3 - Conference contribution

AN - SCOPUS:0030370731

SN - 0819423270

SN - 9780819423276

VL - 2925

SP - 189

EP - 198

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Benaron, David A.

A2 - Chance, Britton

A2 - Mueller, Gerhard J.

T2 - Photon Propagation in Tissues II

Y2 - 7 September 1996 through 8 September 1996

ER -

Quantification of hemoglobin saturation on tissue phantom using phase-modulation spectroscopy

Abstract

Conference

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