TY - GEN
T1 - Quantitative image reconstruction for the RatCAP PET tomograph
AU - Southekal, Sudeepti S.
AU - Purschke, Martin
AU - Park, Sang June
AU - Junnarkar, Sachin S.
AU - Pratte, Jean Francois
AU - Stoll, Sean P.
AU - Sehlyer, David J.
AU - Woody, Craig L.
AU - Vaska, Paul
PY - 2006
Y1 - 2006
N2 - The RatCAP is a miniaturized, head-mounted PET scanner designed to image the brain of conscious rats. This eliminates the need for anesthesia which is known to severely depress brain function. The small field of view of the RatCAP allows a highly accurate Monte Carlo based system matrix for fully 3D maximum likelihood image reconstruction. A number of issues have been addressed in an attempt to realize the full potential of quantitative imaging with RatCAP, including corrections for detector efficiencies, random coincidences, photon scatter and attenuation. In particular, a new method to correct for scatter originating outside the field of view is presented, which takes advantage of the RatCAP iterative reconstruction framework. Preliminary results show significant qualitative and quantitative improvements in the bias and variance of the data.
AB - The RatCAP is a miniaturized, head-mounted PET scanner designed to image the brain of conscious rats. This eliminates the need for anesthesia which is known to severely depress brain function. The small field of view of the RatCAP allows a highly accurate Monte Carlo based system matrix for fully 3D maximum likelihood image reconstruction. A number of issues have been addressed in an attempt to realize the full potential of quantitative imaging with RatCAP, including corrections for detector efficiencies, random coincidences, photon scatter and attenuation. In particular, a new method to correct for scatter originating outside the field of view is presented, which takes advantage of the RatCAP iterative reconstruction framework. Preliminary results show significant qualitative and quantitative improvements in the bias and variance of the data.
UR - https://www.scopus.com/pages/publications/38549170920
U2 - 10.1109/NSSMIC.2006.356445
DO - 10.1109/NSSMIC.2006.356445
M3 - Conference contribution
AN - SCOPUS:38549170920
SN - 1424405610
SN - 9781424405619
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 2736
EP - 2739
BT - 2006 IEEE Nuclear Science Symposium - Conference Record
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
Y2 - 29 October 2006 through 4 November 2006
ER -