QuartataWeb: Integrated Chemical-Protein-Pathway Mapping for Polypharmacology and Chemogenomics

Hongchun Li; Fen Pei; D. Lansing Taylor; Ivet Bahar

doi:10.1093/bioinformatics/btaa210

QuartataWeb: Integrated Chemical-Protein-Pathway Mapping for Polypharmacology and Chemogenomics

Hongchun Li
, Fen Pei
, D. Lansing Taylor
, Ivet Bahar

Laufer Center for Physical and Quantitative Biology

University of Pittsburgh

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

QuartataWeb is a user-friendly server developed for polypharmacological and chemogenomics analyses. Users can easily obtain information on experimentally verified (known) and computationally predicted (new) interactions between 5494 drugs and 2807 human proteins in DrugBank, and between 315 514 chemicals and 9457 human proteins in the STITCH database. In addition, QuartataWeb links targets to KEGG pathways and GO annotations, completing the bridge from drugs/chemicals to function via protein targets and cellular pathways. It allows users to query a series of chemicals, drug combinations or multiple targets, to enable multi-drug, multi-target, multi-pathway analyses, toward facilitating the design of polypharmacological treatments for complex diseases. Availability and implementation: QuartataWeb is freely accessible at http://quartata.csb.pitt.edu.

Original language	English
Pages (from-to)	3935-3937
Number of pages	3
Journal	Bioinformatics
Volume	36
Issue number	12
DOIs	https://doi.org/10.1093/bioinformatics/btaa210
State	Published - Mar 31 2020

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abstract = "QuartataWeb is a user-friendly server developed for polypharmacological and chemogenomics analyses. Users can easily obtain information on experimentally verified (known) and computationally predicted (new) interactions between 5494 drugs and 2807 human proteins in DrugBank, and between 315 514 chemicals and 9457 human proteins in the STITCH database. In addition, QuartataWeb links targets to KEGG pathways and GO annotations, completing the bridge from drugs/chemicals to function via protein targets and cellular pathways. It allows users to query a series of chemicals, drug combinations or multiple targets, to enable multi-drug, multi-target, multi-pathway analyses, toward facilitating the design of polypharmacological treatments for complex diseases. Availability and implementation: QuartataWeb is freely accessible at http://quartata.csb.pitt.edu.",

author = "Hongchun Li and Fen Pei and Taylor, \{D. Lansing\} and Ivet Bahar",

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AU - Li, Hongchun

AU - Pei, Fen

AU - Taylor, D. Lansing

AU - Bahar, Ivet

PY - 2020/3/31

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QuartataWeb: Integrated Chemical-Protein-Pathway Mapping for Polypharmacology and Chemogenomics

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