RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging

P. Vaska; C. L. Woody; D. J. Schlyer; S. Shokouhi; S. P. Stoll; J. F. Pratte; P. O'Connor; S. S. Junnarkar; S. Rescia; B. Yu; M. Porschke; A. Kandasamy; A. Villanueva; A. Kriplani; V. Radeka; N. Volkow; R. Lecomte; R. Fontaine

doi:10.1109/TNS.2004.835740

RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging

P. Vaska
, C. L. Woody
, D. J. Schlyer
, S. Shokouhi
, S. P. Stoll
, J. F. Pratte
, P. O'Connor
, S. S. Junnarkar
, S. Rescia
, B. Yu
, M. Porschke
, A. Kandasamy
, A. Villanueva
, A. Kriplani
, V. Radeka
, N. Volkow
, R. Lecomte
, R. Fontaine

Dept of Biomedical Engineering

Brookhaven National Laboratory
National Institutes of Health
Université de Sherbrooke

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects the neurological state of the animal, complicating the interpretation of PET data. Furthermore, it precludes the use of PET to study the brain during normal behavior. The rat conscious animal PET tomograph (RatCAP) is designed to eliminate the need for anesthesia in rat brain studies. It is a miniaturized full-ring PET scanner that is attached directly to the head, imaging nearly the entire brain. RatCAP utilizes arrays of 2 mm × 2 mm LSO crystals coupled to matching avalanche photodiode arrays, which are in turn read out by full custom integrated circuits. Principal challenges have been addressed considering the physical constraints on size, weight, and heat generation in addition to the usual requirements of small-animal PET, such as high spatial resolution in the presence of parallax error. A partial prototype has been constructed and preliminary measurements and optimization completed. Realistic Monte Carlo simulations have also been carried out to optimize system performance, which is predicted to be competitive with existing microPET systems.

Original language	English
Pages (from-to)	2718-2722
Number of pages	5
Journal	IEEE Transactions on Nuclear Science
Volume	51
Issue number	5 II
DOIs	https://doi.org/10.1109/TNS.2004.835740
State	Published - Oct 2004

Keywords

Biomedical applications of nuclear radiation
Biomedical nuclear imaging
Gamma-ray detectors
Motion compensation
Nervous system
Positron emission tomography (PET)

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10.1109/TNS.2004.835740

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Vaska, P., Woody, C. L., Schlyer, D. J., Shokouhi, S., Stoll, S. P., Pratte, J. F., O'Connor, P., Junnarkar, S. S., Rescia, S., Yu, B., Porschke, M., Kandasamy, A., Villanueva, A., Kriplani, A., Radeka, V., Volkow, N., Lecomte, R., & Fontaine, R. (2004). RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging. IEEE Transactions on Nuclear Science, 51(5 II), 2718-2722. https://doi.org/10.1109/TNS.2004.835740

@article{d76c89e073a146088b7e035b5d231c8c,

title = "RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging",

abstract = "Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects the neurological state of the animal, complicating the interpretation of PET data. Furthermore, it precludes the use of PET to study the brain during normal behavior. The rat conscious animal PET tomograph (RatCAP) is designed to eliminate the need for anesthesia in rat brain studies. It is a miniaturized full-ring PET scanner that is attached directly to the head, imaging nearly the entire brain. RatCAP utilizes arrays of 2 mm × 2 mm LSO crystals coupled to matching avalanche photodiode arrays, which are in turn read out by full custom integrated circuits. Principal challenges have been addressed considering the physical constraints on size, weight, and heat generation in addition to the usual requirements of small-animal PET, such as high spatial resolution in the presence of parallax error. A partial prototype has been constructed and preliminary measurements and optimization completed. Realistic Monte Carlo simulations have also been carried out to optimize system performance, which is predicted to be competitive with existing microPET systems.",

keywords = "Biomedical applications of nuclear radiation, Biomedical nuclear imaging, Gamma-ray detectors, Motion compensation, Nervous system, Positron emission tomography (PET)",

author = "P. Vaska and Woody, \{C. L.\} and Schlyer, \{D. J.\} and S. Shokouhi and Stoll, \{S. P.\} and Pratte, \{J. F.\} and P. O'Connor and Junnarkar, \{S. S.\} and S. Rescia and B. Yu and M. Porschke and A. Kandasamy and A. Villanueva and A. Kriplani and V. Radeka and N. Volkow and R. Lecomte and R. Fontaine",

year = "2004",

month = oct,

doi = "10.1109/TNS.2004.835740",

language = "English",

volume = "51",

pages = "2718--2722",

journal = "IEEE Transactions on Nuclear Science",

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Vaska, P, Woody, CL, Schlyer, DJ, Shokouhi, S, Stoll, SP, Pratte, JF, O'Connor, P, Junnarkar, SS, Rescia, S, Yu, B, Porschke, M, Kandasamy, A, Villanueva, A, Kriplani, A, Radeka, V, Volkow, N, Lecomte, R & Fontaine, R 2004, 'RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging', IEEE Transactions on Nuclear Science, vol. 51, no. 5 II, pp. 2718-2722. https://doi.org/10.1109/TNS.2004.835740

TY - JOUR

T1 - RatCAP

T2 - Miniaturized head-mounted PET for conscious rodent brain imaging

AU - Vaska, P.

AU - Woody, C. L.

AU - Schlyer, D. J.

AU - Shokouhi, S.

AU - Stoll, S. P.

AU - Pratte, J. F.

AU - O'Connor, P.

AU - Junnarkar, S. S.

AU - Rescia, S.

AU - Yu, B.

AU - Porschke, M.

AU - Kandasamy, A.

AU - Villanueva, A.

AU - Kriplani, A.

AU - Radeka, V.

AU - Volkow, N.

AU - Lecomte, R.

AU - Fontaine, R.

PY - 2004/10

Y1 - 2004/10

N2 - Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects the neurological state of the animal, complicating the interpretation of PET data. Furthermore, it precludes the use of PET to study the brain during normal behavior. The rat conscious animal PET tomograph (RatCAP) is designed to eliminate the need for anesthesia in rat brain studies. It is a miniaturized full-ring PET scanner that is attached directly to the head, imaging nearly the entire brain. RatCAP utilizes arrays of 2 mm × 2 mm LSO crystals coupled to matching avalanche photodiode arrays, which are in turn read out by full custom integrated circuits. Principal challenges have been addressed considering the physical constraints on size, weight, and heat generation in addition to the usual requirements of small-animal PET, such as high spatial resolution in the presence of parallax error. A partial prototype has been constructed and preliminary measurements and optimization completed. Realistic Monte Carlo simulations have also been carried out to optimize system performance, which is predicted to be competitive with existing microPET systems.

AB - Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects the neurological state of the animal, complicating the interpretation of PET data. Furthermore, it precludes the use of PET to study the brain during normal behavior. The rat conscious animal PET tomograph (RatCAP) is designed to eliminate the need for anesthesia in rat brain studies. It is a miniaturized full-ring PET scanner that is attached directly to the head, imaging nearly the entire brain. RatCAP utilizes arrays of 2 mm × 2 mm LSO crystals coupled to matching avalanche photodiode arrays, which are in turn read out by full custom integrated circuits. Principal challenges have been addressed considering the physical constraints on size, weight, and heat generation in addition to the usual requirements of small-animal PET, such as high spatial resolution in the presence of parallax error. A partial prototype has been constructed and preliminary measurements and optimization completed. Realistic Monte Carlo simulations have also been carried out to optimize system performance, which is predicted to be competitive with existing microPET systems.

KW - Biomedical applications of nuclear radiation

KW - Biomedical nuclear imaging

KW - Gamma-ray detectors

KW - Motion compensation

KW - Nervous system

KW - Positron emission tomography (PET)

UR - https://www.scopus.com/pages/publications/8344278123

U2 - 10.1109/TNS.2004.835740

DO - 10.1109/TNS.2004.835740

M3 - Article

AN - SCOPUS:8344278123

SN - 0018-9499

VL - 51

SP - 2718

EP - 2722

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

IS - 5 II

ER -

RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging

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Keywords

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