Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation

Lin Jen-Jar Lin; Frederick Miller; Wayne Waltzer; Frederick J. Kaskel; Leonard Arbeit

doi:10.1016/0272-6386(95)90630-4

Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation

Lin Jen-Jar Lin
, Frederick Miller
, Wayne Waltzer
, Frederick J. Kaskel
, Leonard Arbeit

Urology

Stony Brook University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-κ deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.

Original language	English
Pages (from-to)	75-78
Number of pages	4
Journal	American Journal of Kidney Diseases
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/0272-6386(95)90630-4
State	Published - Jan 1995

Keywords

Light and heavy chain deposition disease
immunoglobulin A-κ deposition
posttransplant recurrence
renal transplant
steroid therapy

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10.1016/0272-6386(95)90630-4

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title = "Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation",

abstract = "Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-κ deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.",

keywords = "Light and heavy chain deposition disease, immunoglobulin A-κ deposition, posttransplant recurrence, renal transplant, steroid therapy",

author = "\{Jen-Jar Lin\}, Lin and Frederick Miller and Wayne Waltzer and Kaskel, \{Frederick J.\} and Leonard Arbeit",

year = "1995",

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doi = "10.1016/0272-6386(95)90630-4",

language = "English",

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journal = "American Journal of Kidney Diseases",

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T1 - Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation

AU - Jen-Jar Lin, Lin

AU - Miller, Frederick

AU - Waltzer, Wayne

AU - Kaskel, Frederick J.

AU - Arbeit, Leonard

PY - 1995/1

Y1 - 1995/1

N2 - Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-κ deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.

AB - Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-κ deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.

KW - Light and heavy chain deposition disease

KW - immunoglobulin A-κ deposition

KW - posttransplant recurrence

KW - renal transplant

KW - steroid therapy

UR - https://www.scopus.com/pages/publications/0028890721

U2 - 10.1016/0272-6386(95)90630-4

DO - 10.1016/0272-6386(95)90630-4

M3 - Article

C2 - 7810538

AN - SCOPUS:0028890721

SN - 0272-6386

VL - 25

SP - 75

EP - 78

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

IS - 1

ER -

Recurrence of immunoglobulin A-κ crystalline deposition disease after kidney transplantation

Abstract

Keywords

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