Redox-operated genetic switches: The SoxR and OxyR transcription factors

Pablo J. Pomposiello; Bruce Demple

doi:10.1016/S0167-7799(00)01542-0

Redox-operated genetic switches: The SoxR and OxyR transcription factors

Pablo J. Pomposiello
, Bruce Demple

Pharmacological Sciences

Harvard University

Research output: Contribution to journal › Review article › peer-review

356 Scopus citations

Abstract

Two redox-responsive transcription regulators have been well defined in Escherichia coli and serve as paradigms of redox-operated genetic switches. SoxR contains iron-sulfur centers that activate the protein when they are one-electron oxidized, or nitrosylated by nitric oxide. OxyR contains a pair of redox-active cysteine residues that activate the protein when they are oxidized to form a disulfide bond.

Original language	English
Pages (from-to)	109-114
Number of pages	6
Journal	Trends in Biotechnology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/S0167-7799(00)01542-0
State	Published - Mar 1 2001

Access to Document

10.1016/S0167-7799(00)01542-0

Cite this

@article{5638a32df2ce437cbf4e81d83c68b0b4,

title = "Redox-operated genetic switches: The SoxR and OxyR transcription factors",

abstract = "Two redox-responsive transcription regulators have been well defined in Escherichia coli and serve as paradigms of redox-operated genetic switches. SoxR contains iron-sulfur centers that activate the protein when they are one-electron oxidized, or nitrosylated by nitric oxide. OxyR contains a pair of redox-active cysteine residues that activate the protein when they are oxidized to form a disulfide bond.",

author = "Pomposiello, \{Pablo J.\} and Bruce Demple",

year = "2001",

month = mar,

day = "1",

doi = "10.1016/S0167-7799(00)01542-0",

language = "English",

volume = "19",

pages = "109--114",

journal = "Trends in Biotechnology",

issn = "0167-7799",

number = "3",

}

TY - JOUR

T1 - Redox-operated genetic switches

T2 - The SoxR and OxyR transcription factors

AU - Pomposiello, Pablo J.

AU - Demple, Bruce

PY - 2001/3/1

Y1 - 2001/3/1

N2 - Two redox-responsive transcription regulators have been well defined in Escherichia coli and serve as paradigms of redox-operated genetic switches. SoxR contains iron-sulfur centers that activate the protein when they are one-electron oxidized, or nitrosylated by nitric oxide. OxyR contains a pair of redox-active cysteine residues that activate the protein when they are oxidized to form a disulfide bond.

AB - Two redox-responsive transcription regulators have been well defined in Escherichia coli and serve as paradigms of redox-operated genetic switches. SoxR contains iron-sulfur centers that activate the protein when they are one-electron oxidized, or nitrosylated by nitric oxide. OxyR contains a pair of redox-active cysteine residues that activate the protein when they are oxidized to form a disulfide bond.

UR - https://www.scopus.com/pages/publications/0035283587

U2 - 10.1016/S0167-7799(00)01542-0

DO - 10.1016/S0167-7799(00)01542-0

M3 - Review article

C2 - 11179804

AN - SCOPUS:0035283587

SN - 0167-7799

VL - 19

SP - 109

EP - 114

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 3

ER -

Redox-operated genetic switches: The SoxR and OxyR transcription factors

Abstract

Access to Document

Other files and links

Fingerprint

Cite this