Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator

Elena Hidalgo; Huangen Ding; Bruce Demple

doi:10.1016/S0968-0004(97)01068-2

Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator

Elena Hidalgo
, Huangen Ding
, Bruce Demple

Pharmacological Sciences

Harvard University

Research output: Contribution to journal › Review article › peer-review

123 Scopus citations

Abstract

Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/S0968-0004(97)01068-2
State	Published - Jun 1997

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10.1016/S0968-0004(97)01068-2

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title = "Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator",

abstract = "Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.",

author = "Elena Hidalgo and Huangen Ding and Bruce Demple",

year = "1997",

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T1 - Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator

AU - Hidalgo, Elena

AU - Ding, Huangen

AU - Demple, Bruce

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Y1 - 1997/6

N2 - Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.

AB - Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.

UR - https://www.scopus.com/pages/publications/0030912902

U2 - 10.1016/S0968-0004(97)01068-2

DO - 10.1016/S0968-0004(97)01068-2

M3 - Review article

C2 - 9204707

AN - SCOPUS:0030912902

SN - 0968-0004

VL - 22

SP - 207

EP - 210

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 6

ER -

Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator

Abstract

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