Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5

Sei Jung Lee; Yi Ran No; Duyen T. Dang; Long H. Dang; Vincent W. Yang; Hyunsuk Shim; C. Chris Yun

doi:10.1074/jbc.M113.489708

Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5

Sei Jung Lee
, Yi Ran No
, Duyen T. Dang
, Long H. Dang
, Vincent W. Yang
, Hyunsuk Shim
, C. Chris Yun

Medicine, Chair

Emory University
University of Michigan, Ann Arbor
University of Florida

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Background: LPA induces HIF-1α expression, but the underlying mechanism remains unknown. Results: LPA induced HIF-1α by decreasing p53 expression, and additionally, KLF5 transactivated HIF-1α expression. Conclusion: KLF5 and p53 reciprocally regulate HIF-1α expression. Significance: This study provides a new dimension to understanding how LPA promotes colon cancer.

Original language	English
Pages (from-to)	25244-25253
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	35
DOIs	https://doi.org/10.1074/jbc.M113.489708
State	Published - Aug 30 2013

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title = "Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Kr{\"u}ppel-like factor 5",

abstract = "Background: LPA induces HIF-1α expression, but the underlying mechanism remains unknown. Results: LPA induced HIF-1α by decreasing p53 expression, and additionally, KLF5 transactivated HIF-1α expression. Conclusion: KLF5 and p53 reciprocally regulate HIF-1α expression. Significance: This study provides a new dimension to understanding how LPA promotes colon cancer.",

author = "Lee, \{Sei Jung\} and No, \{Yi Ran\} and Dang, \{Duyen T.\} and Dang, \{Long H.\} and Yang, \{Vincent W.\} and Hyunsuk Shim and Yun, \{C. Chris\}",

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doi = "10.1074/jbc.M113.489708",

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AU - Lee, Sei Jung

AU - No, Yi Ran

AU - Dang, Duyen T.

AU - Dang, Long H.

AU - Yang, Vincent W.

AU - Shim, Hyunsuk

AU - Yun, C. Chris

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Background: LPA induces HIF-1α expression, but the underlying mechanism remains unknown. Results: LPA induced HIF-1α by decreasing p53 expression, and additionally, KLF5 transactivated HIF-1α expression. Conclusion: KLF5 and p53 reciprocally regulate HIF-1α expression. Significance: This study provides a new dimension to understanding how LPA promotes colon cancer.

AB - Background: LPA induces HIF-1α expression, but the underlying mechanism remains unknown. Results: LPA induced HIF-1α by decreasing p53 expression, and additionally, KLF5 transactivated HIF-1α expression. Conclusion: KLF5 and p53 reciprocally regulate HIF-1α expression. Significance: This study provides a new dimension to understanding how LPA promotes colon cancer.

UR - https://www.scopus.com/pages/publications/84883313474

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DO - 10.1074/jbc.M113.489708

M3 - Article

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AN - SCOPUS:84883313474

SN - 0021-9258

VL - 288

SP - 25244

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 35

ER -

Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5

Abstract

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