Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project

Minkyo Song; Harindra Jayasekara; Claudio Pelucchi; Charles S. Rabkin; Kenneth C. Johnson; Jinfu Hu; Domenico Palli; Monica Ferraroni; Linda M. Liao; Rossella Bonzi; David Zaridze; Dmitry Maximovitch; Nuria Aragonés; Vicente Martin; Gemma Castaño-Vinyals; Marcela Guevara; Shoichiro Tsugane; Gerson Shigueaki Hamada; Akihisa Hidaka; Eva Negri; Mary H. Ward; Rashmi Sinha; Areti Lagiou; Pagona Lagiou; Paolo Boffetta; Maria Paula Curado; Nuno Lunet; Jesus Vioque; Zuo Feng Zhang; Carlo La Vecchia; M. Constanza Camargo

doi:10.1007/s10552-023-01829-1

Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project

Minkyo Song
, Harindra Jayasekara
, Claudio Pelucchi
, Charles S. Rabkin
, Kenneth C. Johnson
, Jinfu Hu
, Domenico Palli
, Monica Ferraroni
, Linda M. Liao
, Rossella Bonzi
, David Zaridze
, Dmitry Maximovitch
, Nuria Aragonés
, Vicente Martin
, Gemma Castaño-Vinyals
, Marcela Guevara
, Shoichiro Tsugane
, Gerson Shigueaki Hamada
, Akihisa Hidaka
, Eva Negri

Mary H. Ward, Rashmi Sinha, Areti Lagiou, Pagona Lagiou, Paolo Boffetta, Maria Paula Curado, Nuno Lunet, Jesus Vioque, Zuo Feng Zhang, Carlo La Vecchia, M. Constanza Camargo

Family , Population and Preventative Medicine

National Institutes of Health
Cancer Council Victoria
Monash University
University of Melbourne
University of Milan
University of Ottawa
Harbin Medical University
Institute for the Study and Prevention of Cancer
Blokhin Cancer Research Center
CIBER Epidemiología y Salud Pública (CIBERESP)
Public Health Division
University of Leon
ISGlobal
Hospital del Mar
Pompeu Fabra University
Instituto de Salud Publica, Pamplona
Navarra Medical Research Institute
National Cancer Center Japan
National Institutes of Biomedical Innovation, Health and Nutrition
Nikkei Disease Prevention Center
University of Bologna
University of West Attica
National and Kapodistrian University of Athens
Harvard University
A.C.Camargo Cancer Center
University of Porto
Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR)
Miguel Hernández University
University of California at Los Angeles

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis. Results: A duration of fertility of ≥ 40 years (vs. < 20), was associated with a 25% lower risk of gastric cancer (OR = 0.75; 95% CI: 0.58–0.96). Compared with never use, ever, 5–9 years and ≥ 10 years use of MHT in postmenopausal women, showed ORs of 0.73 (95% CI: 0.58–0.92), 0.53 (95% CI: 0.34–0.84) and 0.71 (95% CI: 0.50–1.00), respectively. The associations were generally similar for anatomical and histologic subtypes. Conclusion: Our results support the hypothesis that reproductive factors and MHT use may lower the risk of gastric cancer in women, regardless of anatomical or histologic subtypes. Given the variation in hormones over the lifespan, studies should address their effects in premenopausal and postmenopausal women. Furthermore, mechanistic studies may inform potential biological processes.

Original language	English
Pages (from-to)	727-737
Number of pages	11
Journal	Cancer Causes and Control
Volume	35
Issue number	4
DOIs	https://doi.org/10.1007/s10552-023-01829-1
State	Published - Apr 2024

Keywords

Estrogens
MHT
Postmenopause
Premenopause

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10.1007/s10552-023-01829-1

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Song, M., Jayasekara, H., Pelucchi, C., Rabkin, C. S., Johnson, K. C., Hu, J., Palli, D., Ferraroni, M., Liao, L. M., Bonzi, R., Zaridze, D., Maximovitch, D., Aragonés, N., Martin, V., Castaño-Vinyals, G., Guevara, M., Tsugane, S., Hamada, G. S., Hidaka, A., ... Camargo, M. C. (2024). Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project. Cancer Causes and Control, 35(4), 727-737. https://doi.org/10.1007/s10552-023-01829-1

@article{9fcadd61440a49ca85ab06a64fa81fd7,

title = "Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project",

abstract = "Background: Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95\% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis. Results: A duration of fertility of ≥ 40 years (vs. < 20), was associated with a 25\% lower risk of gastric cancer (OR = 0.75; 95\% CI: 0.58–0.96). Compared with never use, ever, 5–9 years and ≥ 10 years use of MHT in postmenopausal women, showed ORs of 0.73 (95\% CI: 0.58–0.92), 0.53 (95\% CI: 0.34–0.84) and 0.71 (95\% CI: 0.50–1.00), respectively. The associations were generally similar for anatomical and histologic subtypes. Conclusion: Our results support the hypothesis that reproductive factors and MHT use may lower the risk of gastric cancer in women, regardless of anatomical or histologic subtypes. Given the variation in hormones over the lifespan, studies should address their effects in premenopausal and postmenopausal women. Furthermore, mechanistic studies may inform potential biological processes.",

keywords = "Estrogens, MHT, Postmenopause, Premenopause",

author = "Minkyo Song and Harindra Jayasekara and Claudio Pelucchi and Rabkin, \{Charles S.\} and Johnson, \{Kenneth C.\} and Jinfu Hu and Domenico Palli and Monica Ferraroni and Liao, \{Linda M.\} and Rossella Bonzi and David Zaridze and Dmitry Maximovitch and Nuria Aragon{\'e}s and Vicente Martin and Gemma Casta{\~n}o-Vinyals and Marcela Guevara and Shoichiro Tsugane and Hamada, \{Gerson Shigueaki\} and Akihisa Hidaka and Eva Negri and Ward, \{Mary H.\} and Rashmi Sinha and Areti Lagiou and Pagona Lagiou and Paolo Boffetta and Curado, \{Maria Paula\} and Nuno Lunet and Jesus Vioque and Zhang, \{Zuo Feng\} and \{La Vecchia\}, Carlo and Camargo, \{M. Constanza\}",

note = "Publisher Copyright: {\textcopyright} This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023.",

year = "2024",

month = apr,

doi = "10.1007/s10552-023-01829-1",

language = "English",

volume = "35",

pages = "727--737",

journal = "Cancer Causes and Control",

issn = "0957-5243",

number = "4",

}

Song, M, Jayasekara, H, Pelucchi, C, Rabkin, CS, Johnson, KC, Hu, J, Palli, D, Ferraroni, M, Liao, LM, Bonzi, R, Zaridze, D, Maximovitch, D, Aragonés, N, Martin, V, Castaño-Vinyals, G, Guevara, M, Tsugane, S, Hamada, GS, Hidaka, A, Negri, E, Ward, MH, Sinha, R, Lagiou, A, Lagiou, P, Boffetta, P, Curado, MP, Lunet, N, Vioque, J, Zhang, ZF, La Vecchia, C & Camargo, MC 2024, 'Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project', Cancer Causes and Control, vol. 35, no. 4, pp. 727-737. https://doi.org/10.1007/s10552-023-01829-1

TY - JOUR

T1 - Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project

AU - Song, Minkyo

AU - Jayasekara, Harindra

AU - Pelucchi, Claudio

AU - Rabkin, Charles S.

AU - Johnson, Kenneth C.

AU - Hu, Jinfu

AU - Palli, Domenico

AU - Ferraroni, Monica

AU - Liao, Linda M.

AU - Bonzi, Rossella

AU - Zaridze, David

AU - Maximovitch, Dmitry

AU - Aragonés, Nuria

AU - Martin, Vicente

AU - Castaño-Vinyals, Gemma

AU - Guevara, Marcela

AU - Tsugane, Shoichiro

AU - Hamada, Gerson Shigueaki

AU - Hidaka, Akihisa

AU - Negri, Eva

AU - Ward, Mary H.

AU - Sinha, Rashmi

AU - Lagiou, Areti

AU - Lagiou, Pagona

AU - Boffetta, Paolo

AU - Curado, Maria Paula

AU - Lunet, Nuno

AU - Vioque, Jesus

AU - Zhang, Zuo Feng

AU - La Vecchia, Carlo

AU - Camargo, M. Constanza

PY - 2024/4

Y1 - 2024/4

N2 - Background: Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis. Results: A duration of fertility of ≥ 40 years (vs. < 20), was associated with a 25% lower risk of gastric cancer (OR = 0.75; 95% CI: 0.58–0.96). Compared with never use, ever, 5–9 years and ≥ 10 years use of MHT in postmenopausal women, showed ORs of 0.73 (95% CI: 0.58–0.92), 0.53 (95% CI: 0.34–0.84) and 0.71 (95% CI: 0.50–1.00), respectively. The associations were generally similar for anatomical and histologic subtypes. Conclusion: Our results support the hypothesis that reproductive factors and MHT use may lower the risk of gastric cancer in women, regardless of anatomical or histologic subtypes. Given the variation in hormones over the lifespan, studies should address their effects in premenopausal and postmenopausal women. Furthermore, mechanistic studies may inform potential biological processes.

AB - Background: Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis. Results: A duration of fertility of ≥ 40 years (vs. < 20), was associated with a 25% lower risk of gastric cancer (OR = 0.75; 95% CI: 0.58–0.96). Compared with never use, ever, 5–9 years and ≥ 10 years use of MHT in postmenopausal women, showed ORs of 0.73 (95% CI: 0.58–0.92), 0.53 (95% CI: 0.34–0.84) and 0.71 (95% CI: 0.50–1.00), respectively. The associations were generally similar for anatomical and histologic subtypes. Conclusion: Our results support the hypothesis that reproductive factors and MHT use may lower the risk of gastric cancer in women, regardless of anatomical or histologic subtypes. Given the variation in hormones over the lifespan, studies should address their effects in premenopausal and postmenopausal women. Furthermore, mechanistic studies may inform potential biological processes.

KW - Estrogens

KW - MHT

KW - Postmenopause

KW - Premenopause

UR - https://www.scopus.com/pages/publications/85180190940

U2 - 10.1007/s10552-023-01829-1

DO - 10.1007/s10552-023-01829-1

M3 - Article

C2 - 38123742

AN - SCOPUS:85180190940

SN - 0957-5243

VL - 35

SP - 727

EP - 737

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 4

ER -

Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project

Abstract

Keywords

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