Role of membrane biophysics in Alzheimer's-related cell pathways

Donghui Zhu; Brittani L. Bungart; Xiaoguang Yang; Zhaxybay Zhumadilov; James C.M. Lee; Sholpan Askarova

doi:10.3389/fnins.2015.00186

Role of membrane biophysics in Alzheimer's-related cell pathways

Donghui Zhu
, Brittani L. Bungart
, Xiaoguang Yang
, Zhaxybay Zhumadilov
, James C.M. Lee
, Sholpan Askarova

Biomedical Engineering

Indiana University Bloomington
University of Gothenburg
Washington University St. Louis
Nazarbayev University
University of Illinois at Chicago

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Cellular membrane alterations are commonly observed in many diseases, including Alzheimer's disease (AD). Membrane biophysical properties, such as membrane molecular order, membrane fluidity, organization of lipid rafts, and adhesion between membrane and cytoskeleton, play an important role in various cellular activities and functions. While membrane biophysics impacts a broad range of cellular pathways, this review addresses the role of membrane biophysics in amyloid-β peptide aggregation, Aβ-induced oxidative pathways, amyloid precursor protein processing, and cerebral endothelial functions in AD. Understanding the mechanism(s) underlying the effects of cell membrane properties on cellular processes should shed light on the development of new preventive and therapeutic strategies for this devastating disease.

Original language	English
Article number	186
Journal	Frontiers in Neuroscience
Volume	9
Issue number	MAY
DOIs	https://doi.org/10.3389/fnins.2015.00186
State	Published - 2015

Keywords

Amyloid precursor protein
Amyloid-βpeptide
Cerebral endothelium
Membrane fluidity
Membrane molecular order

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10.3389/fnins.2015.00186

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title = "Role of membrane biophysics in Alzheimer's-related cell pathways",

abstract = "Cellular membrane alterations are commonly observed in many diseases, including Alzheimer's disease (AD). Membrane biophysical properties, such as membrane molecular order, membrane fluidity, organization of lipid rafts, and adhesion between membrane and cytoskeleton, play an important role in various cellular activities and functions. While membrane biophysics impacts a broad range of cellular pathways, this review addresses the role of membrane biophysics in amyloid-β peptide aggregation, Aβ-induced oxidative pathways, amyloid precursor protein processing, and cerebral endothelial functions in AD. Understanding the mechanism(s) underlying the effects of cell membrane properties on cellular processes should shed light on the development of new preventive and therapeutic strategies for this devastating disease.",

keywords = "Amyloid precursor protein, Amyloid-βpeptide, Cerebral endothelium, Membrane fluidity, Membrane molecular order",

author = "Donghui Zhu and Bungart, \{Brittani L.\} and Xiaoguang Yang and Zhaxybay Zhumadilov and Lee, \{James C.M.\} and Sholpan Askarova",

note = "Publisher Copyright: {\textcopyright} 2015 Zhu, Bungart, Yang, Zhumadilov, Lee and Askarova.",

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language = "English",

volume = "9",

journal = "Frontiers in Neuroscience",

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T1 - Role of membrane biophysics in Alzheimer's-related cell pathways

AU - Zhu, Donghui

AU - Bungart, Brittani L.

AU - Yang, Xiaoguang

AU - Zhumadilov, Zhaxybay

AU - Lee, James C.M.

AU - Askarova, Sholpan

PY - 2015

Y1 - 2015

N2 - Cellular membrane alterations are commonly observed in many diseases, including Alzheimer's disease (AD). Membrane biophysical properties, such as membrane molecular order, membrane fluidity, organization of lipid rafts, and adhesion between membrane and cytoskeleton, play an important role in various cellular activities and functions. While membrane biophysics impacts a broad range of cellular pathways, this review addresses the role of membrane biophysics in amyloid-β peptide aggregation, Aβ-induced oxidative pathways, amyloid precursor protein processing, and cerebral endothelial functions in AD. Understanding the mechanism(s) underlying the effects of cell membrane properties on cellular processes should shed light on the development of new preventive and therapeutic strategies for this devastating disease.

AB - Cellular membrane alterations are commonly observed in many diseases, including Alzheimer's disease (AD). Membrane biophysical properties, such as membrane molecular order, membrane fluidity, organization of lipid rafts, and adhesion between membrane and cytoskeleton, play an important role in various cellular activities and functions. While membrane biophysics impacts a broad range of cellular pathways, this review addresses the role of membrane biophysics in amyloid-β peptide aggregation, Aβ-induced oxidative pathways, amyloid precursor protein processing, and cerebral endothelial functions in AD. Understanding the mechanism(s) underlying the effects of cell membrane properties on cellular processes should shed light on the development of new preventive and therapeutic strategies for this devastating disease.

KW - Amyloid precursor protein

KW - Amyloid-βpeptide

KW - Cerebral endothelium

KW - Membrane fluidity

KW - Membrane molecular order

UR - https://www.scopus.com/pages/publications/84930650987

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DO - 10.3389/fnins.2015.00186

M3 - Article

AN - SCOPUS:84930650987

SN - 1662-4548

VL - 9

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

IS - MAY

M1 - 186

ER -

Role of membrane biophysics in Alzheimer's-related cell pathways

Abstract

Keywords

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