Rubella-specific immune complexes after congenital infection and vaccination

Circulating immune complexes which contained rubella-specific immunoglobulins were detected in 21 out of 63 subjects with congenital rubella and in 39 out of 65 subjects vaccinated with attenuated rubella virus, but in none of 43 subjects susceptible to rubella or 87 subjects with remote naturally acquired immunity to rubella. The presence or level of circulating immune complexes and the presence of rubella-specific complexes did not correlate with conventional serum rubella hemagglutination inhibition antibody titers. In the group with congenital infection, the presence of specific complexes many years after birth was associated with late-emerging clinical problems involving several organ systems. In vaccinates, the presence of specific complexes was associated with a higher incidence of side reactions. Two-thirds of the vaccinates and all of those revaccinated showed specific immune complexes as late as 8 months after immunization.