Salmonella Gives MARCH(ing) Orders to MHC-II

Patrick A. McLaughlin; Adrianus W.M. van der Velden

doi:10.1016/j.chom.2016.10.019

Salmonella Gives MARCH(ing) Orders to MHC-II

Patrick A. McLaughlin
, Adrianus W.M. van der Velden

Microbiology and Immunology

Stony Brook University

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

How bacterial pathogens evade adaptive immunity is not well understood. In this issue of Cell Host & Microbe, Bayer-Santos et al. (2016) show that the Salmonella effector protein SteD mediates MARCH8-dependent ubiquitination of class II MHC molecules, thereby inhibiting antigen presentation and limiting T cell responses.

Original language	English
Pages (from-to)	551-552
Number of pages	2
Journal	Cell Host and Microbe
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/j.chom.2016.10.019
State	Published - Nov 9 2016

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10.1016/j.chom.2016.10.019

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title = "Salmonella Gives MARCH(ing) Orders to MHC-II",

abstract = "How bacterial pathogens evade adaptive immunity is not well understood. In this issue of Cell Host \& Microbe, Bayer-Santos et al. (2016) show that the Salmonella effector protein SteD mediates MARCH8-dependent ubiquitination of class II MHC molecules, thereby inhibiting antigen presentation and limiting T cell responses.",

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AU - McLaughlin, Patrick A.

AU - van der Velden, Adrianus W.M.

PY - 2016/11/9

Y1 - 2016/11/9

N2 - How bacterial pathogens evade adaptive immunity is not well understood. In this issue of Cell Host & Microbe, Bayer-Santos et al. (2016) show that the Salmonella effector protein SteD mediates MARCH8-dependent ubiquitination of class II MHC molecules, thereby inhibiting antigen presentation and limiting T cell responses.

AB - How bacterial pathogens evade adaptive immunity is not well understood. In this issue of Cell Host & Microbe, Bayer-Santos et al. (2016) show that the Salmonella effector protein SteD mediates MARCH8-dependent ubiquitination of class II MHC molecules, thereby inhibiting antigen presentation and limiting T cell responses.

UR - https://www.scopus.com/pages/publications/84994719710

U2 - 10.1016/j.chom.2016.10.019

DO - 10.1016/j.chom.2016.10.019

M3 - Short survey

C2 - 27832583

AN - SCOPUS:84994719710

SN - 1931-3128

VL - 20

SP - 551

EP - 552

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 5

ER -

Salmonella Gives MARCH(ing) Orders to MHC-II

Abstract

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