Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration

Alice Alessenko; Wasiuddin A. Khan; William C. Wetsel; Yusuf A. Hannun

doi:10.1016/0006-291X(92)91879-U

Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration

Alice Alessenko
, Wasiuddin A. Khan
, William C. Wetsel
, Yusuf A. Hannun

Cancer Center

Academy of Sciences
Duke University
National Institutes of Health

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Using isoenzyme-specific antisera, protein kinase C (PKC) α and PKC δ were detected in total liver homogenate and in isolated nuclei. PKC β_I, β_II, ε, ε′, and ζ were not detected. During liver regeneration, nuclear PKCα levels decreased while PKCδ levels increased. These studies demonstrate, for the first time, the presence of a calcium-independent PKC isoenzyme in liver nuclei and suggest that PKCα and PKCδ may have different roles in liver regeneration and cell proliferation.

Original language	English
Pages (from-to)	1333-1339
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	182
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(92)91879-U
State	Published - Feb 14 1992

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title = "Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration",

abstract = "Using isoenzyme-specific antisera, protein kinase C (PKC) α and PKC δ were detected in total liver homogenate and in isolated nuclei. PKC βI, βII, ε, ε′, and ζ were not detected. During liver regeneration, nuclear PKCα levels decreased while PKCδ levels increased. These studies demonstrate, for the first time, the presence of a calcium-independent PKC isoenzyme in liver nuclei and suggest that PKCα and PKCδ may have different roles in liver regeneration and cell proliferation.",

author = "Alice Alessenko and Khan, \{Wasiuddin A.\} and Wetsel, \{William C.\} and Hannun, \{Yusuf A.\}",

year = "1992",

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pages = "1333--1339",

journal = "Biochemical and Biophysical Research Communications",

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T1 - Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration

AU - Alessenko, Alice

AU - Khan, Wasiuddin A.

AU - Wetsel, William C.

AU - Hannun, Yusuf A.

PY - 1992/2/14

Y1 - 1992/2/14

N2 - Using isoenzyme-specific antisera, protein kinase C (PKC) α and PKC δ were detected in total liver homogenate and in isolated nuclei. PKC βI, βII, ε, ε′, and ζ were not detected. During liver regeneration, nuclear PKCα levels decreased while PKCδ levels increased. These studies demonstrate, for the first time, the presence of a calcium-independent PKC isoenzyme in liver nuclei and suggest that PKCα and PKCδ may have different roles in liver regeneration and cell proliferation.

AB - Using isoenzyme-specific antisera, protein kinase C (PKC) α and PKC δ were detected in total liver homogenate and in isolated nuclei. PKC βI, βII, ε, ε′, and ζ were not detected. During liver regeneration, nuclear PKCα levels decreased while PKCδ levels increased. These studies demonstrate, for the first time, the presence of a calcium-independent PKC isoenzyme in liver nuclei and suggest that PKCα and PKCδ may have different roles in liver regeneration and cell proliferation.

UR - https://www.scopus.com/pages/publications/0026539220

U2 - 10.1016/0006-291X(92)91879-U

DO - 10.1016/0006-291X(92)91879-U

M3 - Article

C2 - 1540177

AN - SCOPUS:0026539220

SN - 0006-291X

VL - 182

SP - 1333

EP - 1339

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration

Abstract

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