Self-assembled magnetic bead biosensor for measuring bacterial growth and antimicrobial susceptibility testing

Paivo Kinnunen; Brandon H. McNaughton; Theodore Albertson; Irene Sinn; Sima Mofakham; Remy Elbez; Duane W. Newton; Alan Hunt; Raoul Kopelman

doi:10.1002/smll.201200110

Self-assembled magnetic bead biosensor for measuring bacterial growth and antimicrobial susceptibility testing

Paivo Kinnunen
, Brandon H. McNaughton
, Theodore Albertson
, Irene Sinn
, Sima Mofakham
, Remy Elbez
, Duane W. Newton
, Alan Hunt
, Raoul Kopelman

Surgery

University of Michigan, Ann Arbor

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth-based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self-assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6-24 hours. A 16-well prototype is also constructed for simple and robust observation of the self-assembled AMBR biosensors.

Original language	English
Pages (from-to)	2477-2482
Number of pages	6
Journal	Small
Volume	8
Issue number	16
DOIs	https://doi.org/10.1002/smll.201200110
State	Published - Aug 20 2012

Keywords

antimicrobial susceptibility testing
asynchronous magnetic bead rotation
biosensors
magnetic beads
self-assembly

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10.1002/smll.201200110

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abstract = "Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth-based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self-assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6-24 hours. A 16-well prototype is also constructed for simple and robust observation of the self-assembled AMBR biosensors.",

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AU - Kinnunen, Paivo

AU - McNaughton, Brandon H.

AU - Albertson, Theodore

AU - Sinn, Irene

AU - Mofakham, Sima

AU - Elbez, Remy

AU - Newton, Duane W.

AU - Hunt, Alan

AU - Kopelman, Raoul

PY - 2012/8/20

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AB - Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth-based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self-assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6-24 hours. A 16-well prototype is also constructed for simple and robust observation of the self-assembled AMBR biosensors.

KW - antimicrobial susceptibility testing

KW - asynchronous magnetic bead rotation

KW - biosensors

KW - magnetic beads

KW - self-assembly

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JO - Small

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ER -

Self-assembled magnetic bead biosensor for measuring bacterial growth and antimicrobial susceptibility testing

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Keywords

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