Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography

on behalf of the OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group

doi:10.1117/12.2077797

Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography

on behalf of the OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group

Ophthalmology

University of Iowa
Continuum Health Partners, Inc.
University of Rochester
Zeiss-Meditec, Inc.
University of California at Davis

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

12 Scopus citations

Abstract

Recent studies have shown that the Bruch's membrane (BM) and retinal pigment epithelium (RPE), visualized on spectral-domain optical coherence tomography (SD-OCT), is deformed anteriorly towards the vitreous in patients with intracranial hypertension and papilledema. The BM/RPE shape has been quantified using a statistical-shape-model approach; however, to date, the approach has involved the tedious and time-consuming manual placement of landmarks and correspondingly, only the shape (and shape changes) of a limited number of patients has been studied. In this work, we first present a semi-automated approach for the extraction of 20 landmarks along the BM from an optic-nerve-head (ONH) centered OCT slice from each patient. In the approach, after the manual placement of the two Bruch's membrane opening (BMO) points, the remaining 18 landmarks are automatically determined using a graph-based segmentation approach. We apply the approach to the OCT scans of 116 patients (at baseline) enrolled in the Idiopathic Intracranial Hypertension Treatment Trial and generate a statistical shape model using principal components analysis. Using the resulting shape model, the coefficient (shape measure) corresponding to the second principal component (eigenvector) for each set of landmarks indicates the degree of the BM/RPE is oriented away from the vitreous. Using a subset of 20 patients, we compare the shape measure computed using this semi-automated approach with the resulting shape measure when (1) all landmarks are specified manually (Experiment I); and (2) a different expert specifies the two BMO points (Experiment II). In each case, a correlation coefficient ≥ 0.99 is obtained.

Original language	English
Title of host publication	Medical Imaging 2015
Subtitle of host publication	Biomedical Applications in Molecular, Structural, and Functional Imaging
Editors	Barjor Gimi, Robert C. Molthen
Publisher	SPIE
ISBN (Electronic)	9781628415070
DOIs	https://doi.org/10.1117/12.2077797
State	Published - 2015
Event	Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging - Orlando, United States Duration: Feb 24 2015 → Feb 26 2015

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9417
ISSN (Print)	1605-7422

Conference

Conference	Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
Country/Territory	United States
City	Orlando
Period	02/24/15 → 02/26/15

Keywords

Bruch's membrane
Optical coherence tomography
Papilledema
Shape analysis

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10.1117/12.2077797

Cite this

on behalf of the OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group (2015). Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography. In B. Gimi, & R. C. Molthen (Eds.), Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging Article 941721 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9417). SPIE. https://doi.org/10.1117/12.2077797

on behalf of the OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group. / Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography. Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. editor / Barjor Gimi ; Robert C. Molthen. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{1bb17a48816345348e7ff24bc66b433e,

title = "Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography",

abstract = "Recent studies have shown that the Bruch's membrane (BM) and retinal pigment epithelium (RPE), visualized on spectral-domain optical coherence tomography (SD-OCT), is deformed anteriorly towards the vitreous in patients with intracranial hypertension and papilledema. The BM/RPE shape has been quantified using a statistical-shape-model approach; however, to date, the approach has involved the tedious and time-consuming manual placement of landmarks and correspondingly, only the shape (and shape changes) of a limited number of patients has been studied. In this work, we first present a semi-automated approach for the extraction of 20 landmarks along the BM from an optic-nerve-head (ONH) centered OCT slice from each patient. In the approach, after the manual placement of the two Bruch's membrane opening (BMO) points, the remaining 18 landmarks are automatically determined using a graph-based segmentation approach. We apply the approach to the OCT scans of 116 patients (at baseline) enrolled in the Idiopathic Intracranial Hypertension Treatment Trial and generate a statistical shape model using principal components analysis. Using the resulting shape model, the coefficient (shape measure) corresponding to the second principal component (eigenvector) for each set of landmarks indicates the degree of the BM/RPE is oriented away from the vitreous. Using a subset of 20 patients, we compare the shape measure computed using this semi-automated approach with the resulting shape measure when (1) all landmarks are specified manually (Experiment I); and (2) a different expert specifies the two BMO points (Experiment II). In each case, a correlation coefficient ≥ 0.99 is obtained.",

keywords = "Bruch's membrane, Optical coherence tomography, Papilledema, Shape analysis",

author = "\{on behalf of the OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group\} and Wang, \{Jui Kai\} and Sibony, \{Patrick A.\} and Kardon, \{Randy H.\} and Kupersmith, \{Mark J.\} and Garvin, \{Mona K.\} and Peggy Auinger and Mary Durbin and Steven Feldon and John Keltner and Kim Plumb and Werner, \{John S.\}",

note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging ; Conference date: 24-02-2015 Through 26-02-2015",

year = "2015",

doi = "10.1117/12.2077797",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Barjor Gimi and Molthen, \{Robert C.\}",

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on behalf of the OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group 2015, Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography. in B Gimi & RC Molthen (eds), Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging., 941721, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9417, SPIE, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, Orlando, United States, 02/24/15. https://doi.org/10.1117/12.2077797

Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography. / on behalf of the OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group.
Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. ed. / Barjor Gimi; Robert C. Molthen. SPIE, 2015. 941721 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9417).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Wang, Jui Kai

AU - Sibony, Patrick A.

AU - Kardon, Randy H.

AU - Kupersmith, Mark J.

AU - Garvin, Mona K.

AU - Auinger, Peggy

AU - Durbin, Mary

AU - Feldon, Steven

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AU - Werner, John S.

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N2 - Recent studies have shown that the Bruch's membrane (BM) and retinal pigment epithelium (RPE), visualized on spectral-domain optical coherence tomography (SD-OCT), is deformed anteriorly towards the vitreous in patients with intracranial hypertension and papilledema. The BM/RPE shape has been quantified using a statistical-shape-model approach; however, to date, the approach has involved the tedious and time-consuming manual placement of landmarks and correspondingly, only the shape (and shape changes) of a limited number of patients has been studied. In this work, we first present a semi-automated approach for the extraction of 20 landmarks along the BM from an optic-nerve-head (ONH) centered OCT slice from each patient. In the approach, after the manual placement of the two Bruch's membrane opening (BMO) points, the remaining 18 landmarks are automatically determined using a graph-based segmentation approach. We apply the approach to the OCT scans of 116 patients (at baseline) enrolled in the Idiopathic Intracranial Hypertension Treatment Trial and generate a statistical shape model using principal components analysis. Using the resulting shape model, the coefficient (shape measure) corresponding to the second principal component (eigenvector) for each set of landmarks indicates the degree of the BM/RPE is oriented away from the vitreous. Using a subset of 20 patients, we compare the shape measure computed using this semi-automated approach with the resulting shape measure when (1) all landmarks are specified manually (Experiment I); and (2) a different expert specifies the two BMO points (Experiment II). In each case, a correlation coefficient ≥ 0.99 is obtained.

AB - Recent studies have shown that the Bruch's membrane (BM) and retinal pigment epithelium (RPE), visualized on spectral-domain optical coherence tomography (SD-OCT), is deformed anteriorly towards the vitreous in patients with intracranial hypertension and papilledema. The BM/RPE shape has been quantified using a statistical-shape-model approach; however, to date, the approach has involved the tedious and time-consuming manual placement of landmarks and correspondingly, only the shape (and shape changes) of a limited number of patients has been studied. In this work, we first present a semi-automated approach for the extraction of 20 landmarks along the BM from an optic-nerve-head (ONH) centered OCT slice from each patient. In the approach, after the manual placement of the two Bruch's membrane opening (BMO) points, the remaining 18 landmarks are automatically determined using a graph-based segmentation approach. We apply the approach to the OCT scans of 116 patients (at baseline) enrolled in the Idiopathic Intracranial Hypertension Treatment Trial and generate a statistical shape model using principal components analysis. Using the resulting shape model, the coefficient (shape measure) corresponding to the second principal component (eigenvector) for each set of landmarks indicates the degree of the BM/RPE is oriented away from the vitreous. Using a subset of 20 patients, we compare the shape measure computed using this semi-automated approach with the resulting shape measure when (1) all landmarks are specified manually (Experiment I); and (2) a different expert specifies the two BMO points (Experiment II). In each case, a correlation coefficient ≥ 0.99 is obtained.

KW - Bruch's membrane

KW - Optical coherence tomography

KW - Papilledema

KW - Shape analysis

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BT - Medical Imaging 2015

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ER -

on behalf of the OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group. Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography. In Gimi B, Molthen RC, editors, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE. 2015. 941721. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2077797

Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography

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Keywords

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