Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium

Shu Chun Chuang; Antonio Agudo; Wolfgang Ahrens; Devasena Anantharaman; Simone Benhamou; Stefania Boccia; Chu Chen; David I. Conway; Eleonora Fabianova; Richard B. Hayes; Claire M. Healy; Ivana Holcatova; Kristina Kjaerheim; Pagona Lagiou; Philip Lazarus; Tatiana V. Macfarlane; Manoj B. Mahimkar; Dana Mates; Keitaro Matsuo; Franco Merletti; Andres Metspalu; Hal Morgenstern; Joshua Muscat; Gabriella Cadoni; Andrew F. Olshan; Mark Purdue; Heribert Ramroth; Peter Rudnai; Stephen M. Schwartz; Lorenzo Simonato; Elaine M. Smith; Erich M. Sturgis; Neonilia Szeszenia-Dabrowska; Renato Talamini; Peter Thomson; Qingyi Wei; David Zaridze; Zuo Feng Zhang; Ariana Znaor; Paul Brennan; Paolo Boffetta; Mia Hashibe

doi:10.3389/fonc.2011.00013

Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium

Shu Chun Chuang
, Antonio Agudo
, Wolfgang Ahrens
, Devasena Anantharaman
, Simone Benhamou
, Stefania Boccia
, Chu Chen
, David I. Conway
, Eleonora Fabianova
, Richard B. Hayes
, Claire M. Healy
, Ivana Holcatova
, Kristina Kjaerheim
, Pagona Lagiou
, Philip Lazarus
, Tatiana V. Macfarlane
, Manoj B. Mahimkar
, Dana Mates
, Keitaro Matsuo
, Franco Merletti

Andres Metspalu, Hal Morgenstern, Joshua Muscat, Gabriella Cadoni, Andrew F. Olshan, Mark Purdue, Heribert Ramroth, Peter Rudnai, Stephen M. Schwartz, Lorenzo Simonato, Elaine M. Smith, Erich M. Sturgis, Neonilia Szeszenia-Dabrowska, Renato Talamini, Peter Thomson, Qingyi Wei, David Zaridze, Zuo Feng Zhang, Ariana Znaor, Paul Brennan, Paolo Boffetta, Mia Hashibe

International Agency for Research on Cancer
Imperial College London
Institute Catala Oncologia
Leibniz Institute for Prevention Research and Epidemiology
Tata Memorial Hospital
Institut national de la santé et de la recherche médicale
Catholic University of the Sacred Heart
IRCCS San Raffaele Pisana - Roma
Fred Hutchinson Cancer Research Center
University of Glasgow
Specialized State Health Institute
New York University
Trinity College Dublin
Charles University
Cancer Registry of Norway Institute of Population-Based Cancer Research
National and Kapodistrian University of Athens
Pennsylvania State University
University of Aberdeen
National Institute of Public Health
Aichi Cancer Center Hospital and Research Institute
University of Turin
University of Tartu
University of Michigan, Ann Arbor
University of North Carolina at Chapel Hill
National Institutes of Health
Heidelberg University
Hungarian National Institute of Environmental Health
University of Padua
University of Iowa
University of Texas MD Anderson Cancer Center
Nofer Institute of Occupational Medicine
IRCCS Centro di Riferimento Oncologico - Aviano PN
Newcastle University
Blokhin Cancer Research Center
University of California at Los Angeles
Croatian National Institute of Public Health
University of Utah

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.

Original language	English
Article number	00013
Journal	Frontiers in Oncology
Volume	1
Issue number	JUL
DOIs	https://doi.org/10.3389/fonc.2011.00013
State	Published - 2011

Keywords

Head and neck cancer
INHANCE
SNP

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10.3389/fonc.2011.00013

Cite this

Chuang, S. C., Agudo, A., Ahrens, W., Anantharaman, D., Benhamou, S., Boccia, S., Chen, C., Conway, D. I., Fabianova, E., Hayes, R. B., Healy, C. M., Holcatova, I., Kjaerheim, K., Lagiou, P., Lazarus, P., Macfarlane, T. V., Mahimkar, M. B., Mates, D., Matsuo, K., ... Hashibe, M. (2011). Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium. Frontiers in Oncology, 1(JUL), Article 00013. https://doi.org/10.3389/fonc.2011.00013

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title = "Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium",

abstract = "Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95\% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95\% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95\% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95\% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95\% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95\% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20\%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.",

keywords = "Head and neck cancer, INHANCE, SNP",

author = "Chuang, \{Shu Chun\} and Antonio Agudo and Wolfgang Ahrens and Devasena Anantharaman and Simone Benhamou and Stefania Boccia and Chu Chen and Conway, \{David I.\} and Eleonora Fabianova and Hayes, \{Richard B.\} and Healy, \{Claire M.\} and Ivana Holcatova and Kristina Kjaerheim and Pagona Lagiou and Philip Lazarus and Macfarlane, \{Tatiana V.\} and Mahimkar, \{Manoj B.\} and Dana Mates and Keitaro Matsuo and Franco Merletti and Andres Metspalu and Hal Morgenstern and Joshua Muscat and Gabriella Cadoni and Olshan, \{Andrew F.\} and Mark Purdue and Heribert Ramroth and Peter Rudnai and Schwartz, \{Stephen M.\} and Lorenzo Simonato and Smith, \{Elaine M.\} and Sturgis, \{Erich M.\} and Neonilia Szeszenia-Dabrowska and Renato Talamini and Peter Thomson and Qingyi Wei and David Zaridze and Zhang, \{Zuo Feng\} and Ariana Znaor and Paul Brennan and Paolo Boffetta and Mia Hashibe",

year = "2011",

doi = "10.3389/fonc.2011.00013",

language = "English",

volume = "1",

journal = "Frontiers in Oncology",

issn = "2234-943X",

number = "JUL",

}

Chuang, SC, Agudo, A, Ahrens, W, Anantharaman, D, Benhamou, S, Boccia, S, Chen, C, Conway, DI, Fabianova, E, Hayes, RB, Healy, CM, Holcatova, I, Kjaerheim, K, Lagiou, P, Lazarus, P, Macfarlane, TV, Mahimkar, MB, Mates, D, Matsuo, K, Merletti, F, Metspalu, A, Morgenstern, H, Muscat, J, Cadoni, G, Olshan, AF, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, SM, Simonato, L, Smith, EM, Sturgis, EM, Szeszenia-Dabrowska, N, Talamini, R, Thomson, P, Wei, Q, Zaridze, D, Zhang, ZF, Znaor, A, Brennan, P, Boffetta, P & Hashibe, M 2011, 'Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium', Frontiers in Oncology, vol. 1, no. JUL, 00013. https://doi.org/10.3389/fonc.2011.00013

TY - JOUR

T1 - Sequence variants and the risk of head and neck cancer

T2 - Pooled analysis in the INHANCE consortium

AU - Chuang, Shu Chun

AU - Agudo, Antonio

AU - Ahrens, Wolfgang

AU - Anantharaman, Devasena

AU - Benhamou, Simone

AU - Boccia, Stefania

AU - Chen, Chu

AU - Conway, David I.

AU - Fabianova, Eleonora

AU - Hayes, Richard B.

AU - Healy, Claire M.

AU - Holcatova, Ivana

AU - Kjaerheim, Kristina

AU - Lagiou, Pagona

AU - Lazarus, Philip

AU - Macfarlane, Tatiana V.

AU - Mahimkar, Manoj B.

AU - Mates, Dana

AU - Matsuo, Keitaro

AU - Merletti, Franco

AU - Metspalu, Andres

AU - Morgenstern, Hal

AU - Muscat, Joshua

AU - Cadoni, Gabriella

AU - Olshan, Andrew F.

AU - Purdue, Mark

AU - Ramroth, Heribert

AU - Rudnai, Peter

AU - Schwartz, Stephen M.

AU - Simonato, Lorenzo

AU - Smith, Elaine M.

AU - Sturgis, Erich M.

AU - Szeszenia-Dabrowska, Neonilia

AU - Talamini, Renato

AU - Thomson, Peter

AU - Wei, Qingyi

AU - Zaridze, David

AU - Zhang, Zuo Feng

AU - Znaor, Ariana

AU - Brennan, Paul

AU - Boffetta, Paolo

AU - Hashibe, Mia

PY - 2011

Y1 - 2011

N2 - Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.

AB - Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.

KW - Head and neck cancer

KW - INHANCE

KW - SNP

UR - https://www.scopus.com/pages/publications/84876000480

U2 - 10.3389/fonc.2011.00013

DO - 10.3389/fonc.2011.00013

M3 - Article

AN - SCOPUS:84876000480

SN - 2234-943X

VL - 1

JO - Frontiers in Oncology

JF - Frontiers in Oncology

IS - JUL

M1 - 00013

ER -

Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium

Abstract

Keywords

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