Serotonin receptors as targets of antipsychotic medications

Anissa Abi-Dargham; John Krystal

Serotonin receptors as targets of antipsychotic medications

Anissa Abi-Dargham
, John Krystal

Psychiatry

Yale University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

12 Scopus citations

Abstract

A dysfunction of the 5-hydroxytryptamine (5-HT) function in schizophrenia was first postulated because of the structural similarity between 5-HT and the hallucinogenic drug lysergic acid diethylamide (LSD).1,2 However, the recognition that LSD-induced psychosis differed clinically from the schizophrenic psychotic episodes3 contributed to the eclipse of 5-HT-related hypotheses of schizophrenia by dopaminergic theories during the 1970s and early 1980s. The interest in the role of 5-HT in schizophrenia was renewed after the introduction of clozapine in the U.S., a drug with negligible liability for extrapyramidal side effects (EPS) and superior antipsychotic properties compared to.

Original language	English
Title of host publication	Neurotransmitter Receptors in Actions of Antipsychotic Medications
Publisher	CRC Press
Pages	79-107
Number of pages	29
ISBN (Electronic)	9781420041774
ISBN (Print)	0849307449, 9780849307447
State	Published - Jan 1 2000

Cite this

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abstract = "A dysfunction of the 5-hydroxytryptamine (5-HT) function in schizophrenia was first postulated because of the structural similarity between 5-HT and the hallucinogenic drug lysergic acid diethylamide (LSD).1,2 However, the recognition that LSD-induced psychosis differed clinically from the schizophrenic psychotic episodes3 contributed to the eclipse of 5-HT-related hypotheses of schizophrenia by dopaminergic theories during the 1970s and early 1980s. The interest in the role of 5-HT in schizophrenia was renewed after the introduction of clozapine in the U.S., a drug with negligible liability for extrapyramidal side effects (EPS) and superior antipsychotic properties compared to.",

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N2 - A dysfunction of the 5-hydroxytryptamine (5-HT) function in schizophrenia was first postulated because of the structural similarity between 5-HT and the hallucinogenic drug lysergic acid diethylamide (LSD).1,2 However, the recognition that LSD-induced psychosis differed clinically from the schizophrenic psychotic episodes3 contributed to the eclipse of 5-HT-related hypotheses of schizophrenia by dopaminergic theories during the 1970s and early 1980s. The interest in the role of 5-HT in schizophrenia was renewed after the introduction of clozapine in the U.S., a drug with negligible liability for extrapyramidal side effects (EPS) and superior antipsychotic properties compared to.

AB - A dysfunction of the 5-hydroxytryptamine (5-HT) function in schizophrenia was first postulated because of the structural similarity between 5-HT and the hallucinogenic drug lysergic acid diethylamide (LSD).1,2 However, the recognition that LSD-induced psychosis differed clinically from the schizophrenic psychotic episodes3 contributed to the eclipse of 5-HT-related hypotheses of schizophrenia by dopaminergic theories during the 1970s and early 1980s. The interest in the role of 5-HT in schizophrenia was renewed after the introduction of clozapine in the U.S., a drug with negligible liability for extrapyramidal side effects (EPS) and superior antipsychotic properties compared to.

UR - https://www.scopus.com/pages/publications/0002050485

M3 - Chapter

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SN - 9780849307447

SP - 79

EP - 107

BT - Neurotransmitter Receptors in Actions of Antipsychotic Medications

PB - CRC Press

ER -

Serotonin receptors as targets of antipsychotic medications

Abstract

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