Serotypic analysis of VP3 and VP7 neutralization escape mutants of rhesus rotavirus

R. D. Shaw; E. R. Mackow; M. L. Dyall-Smith; I. Lazdins; I. H. Holmes; H. B. Greenberg

doi:10.1128/jvi.62.9.3509-3512.1988

Serotypic analysis of VP3 and VP7 neutralization escape mutants of rhesus rotavirus

R. D. Shaw
, E. R. Mackow
, M. L. Dyall-Smith
, I. Lazdins
, I. H. Holmes
, H. B. Greenberg

Microbiology and Immunology

Stanford University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Neutralization escape mutants of simian rotaviruses (rhesus rotavirus and SA11) were tested in hemagglutination inhibition and neutralization assays against hyperimmune and infection sera to determine if mutation in an immunodominant epitope could enable neutralization escape. An SA11 mutant with a new glycosylation site at amino acid 211 of VP7 was shown to escape neutralization by hyperimmune but not infection sera.

Original language	English
Pages (from-to)	3509-3512
Number of pages	4
Journal	Journal of Virology
Volume	62
Issue number	9
DOIs	https://doi.org/10.1128/jvi.62.9.3509-3512.1988
State	Published - 1988

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10.1128/jvi.62.9.3509-3512.1988

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title = "Serotypic analysis of VP3 and VP7 neutralization escape mutants of rhesus rotavirus",

abstract = "Neutralization escape mutants of simian rotaviruses (rhesus rotavirus and SA11) were tested in hemagglutination inhibition and neutralization assays against hyperimmune and infection sera to determine if mutation in an immunodominant epitope could enable neutralization escape. An SA11 mutant with a new glycosylation site at amino acid 211 of VP7 was shown to escape neutralization by hyperimmune but not infection sera.",

author = "Shaw, \{R. D.\} and Mackow, \{E. R.\} and Dyall-Smith, \{M. L.\} and I. Lazdins and Holmes, \{I. H.\} and Greenberg, \{H. B.\}",

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T1 - Serotypic analysis of VP3 and VP7 neutralization escape mutants of rhesus rotavirus

AU - Shaw, R. D.

AU - Mackow, E. R.

AU - Dyall-Smith, M. L.

AU - Lazdins, I.

AU - Holmes, I. H.

AU - Greenberg, H. B.

PY - 1988

Y1 - 1988

N2 - Neutralization escape mutants of simian rotaviruses (rhesus rotavirus and SA11) were tested in hemagglutination inhibition and neutralization assays against hyperimmune and infection sera to determine if mutation in an immunodominant epitope could enable neutralization escape. An SA11 mutant with a new glycosylation site at amino acid 211 of VP7 was shown to escape neutralization by hyperimmune but not infection sera.

AB - Neutralization escape mutants of simian rotaviruses (rhesus rotavirus and SA11) were tested in hemagglutination inhibition and neutralization assays against hyperimmune and infection sera to determine if mutation in an immunodominant epitope could enable neutralization escape. An SA11 mutant with a new glycosylation site at amino acid 211 of VP7 was shown to escape neutralization by hyperimmune but not infection sera.

UR - https://www.scopus.com/pages/publications/0023689275

U2 - 10.1128/jvi.62.9.3509-3512.1988

DO - 10.1128/jvi.62.9.3509-3512.1988

M3 - Article

C2 - 2457117

AN - SCOPUS:0023689275

SN - 0022-538X

VL - 62

SP - 3509

EP - 3512

JO - Journal of Virology

JF - Journal of Virology

IS - 9

ER -

Serotypic analysis of VP3 and VP7 neutralization escape mutants of rhesus rotavirus

Abstract

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