Sex differences in asthma and gastroesophageal reflux disease incidence among the World Trade Center Health Program General Responder Cohort

Jieying Jiang; Nikolina Icitovic; Michael A. Crane; Christopher R. Dasaro; Julia R. Kaplan; Roberto G. Lucchini; Benjamin J. Luft; Jacqueline M. Moline; Lakshmi Pendem; Moshe Shapiro; Iris G. Udasin; Andrew C. Todd; Susan L. Teitelbaum

doi:10.1002/ajim.22634

Sex differences in asthma and gastroesophageal reflux disease incidence among the World Trade Center Health Program General Responder Cohort

Jieying Jiang
, Nikolina Icitovic
, Michael A. Crane
, Christopher R. Dasaro
, Julia R. Kaplan
, Roberto G. Lucchini
, Benjamin J. Luft
, Jacqueline M. Moline
, Lakshmi Pendem
, Moshe Shapiro
, Iris G. Udasin
, Andrew C. Todd
, Susan L. Teitelbaum

Infectious Diseases

Icahn School of Medicine at Mount Sinai
Hofstra North Shore-Long Island Jewish School of Medicine
Robert Wood Johnson University Hospital

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

BACKGROUND: Asthma and gastroesophageal reflux disease (GERD) are two common conditions among the responders to the WTC attacks. This study examined whether the cumulative incidence rates of asthma and GERD differed by sex among 24,022 and 23,557 WTC responders, respectively.

METHODS: Cox proportional hazards regression was used to examine the sex difference in the rate of onset of physician-diagnosed asthma or GERD, from 9/12/2001 through 12/31/2015.

RESULTS: The cumulative incidence of asthma reached 23% for women and 17% for men by the end of 2015, and the cumulative incidence of GERD reached 45% for women and 38% for men. Comparing women to men, the hazard ratio was 1.48 (95% confidence interval (CI): 1.27, 1.74) for asthma, and 1.25 (95% CI: 1.13, 1.38) for GERD.

CONCLUSIONS: WTC general responders have a substantial burden of asthma and GERD, with higher incidence in women. Am. J. Ind. Med. 59:815-822, 2016.

Original language	English
Pages (from-to)	815-822
Number of pages	8
Journal	American Journal of Industrial Medicine
Volume	59
Issue number	9
DOIs	https://doi.org/10.1002/ajim.22634
State	Published - Sep 1 2016

Keywords

9/11
asthma
GERD
World Trade Center

Access to Document

10.1002/ajim.22634

Cite this

Jiang, J., Icitovic, N., Crane, M. A., Dasaro, C. R., Kaplan, J. R., Lucchini, R. G., Luft, B. J., Moline, J. M., Pendem, L., Shapiro, M., Udasin, I. G., Todd, A. C., & Teitelbaum, S. L. (2016). Sex differences in asthma and gastroesophageal reflux disease incidence among the World Trade Center Health Program General Responder Cohort. American Journal of Industrial Medicine, 59(9), 815-822. https://doi.org/10.1002/ajim.22634

@article{4ef0da71ec7a4017a193784a62ec568b,

title = "Sex differences in asthma and gastroesophageal reflux disease incidence among the World Trade Center Health Program General Responder Cohort",

abstract = "BACKGROUND: Asthma and gastroesophageal reflux disease (GERD) are two common conditions among the responders to the WTC attacks. This study examined whether the cumulative incidence rates of asthma and GERD differed by sex among 24,022 and 23,557 WTC responders, respectively.METHODS: Cox proportional hazards regression was used to examine the sex difference in the rate of onset of physician-diagnosed asthma or GERD, from 9/12/2001 through 12/31/2015.RESULTS: The cumulative incidence of asthma reached 23\% for women and 17\% for men by the end of 2015, and the cumulative incidence of GERD reached 45\% for women and 38\% for men. Comparing women to men, the hazard ratio was 1.48 (95\% confidence interval (CI): 1.27, 1.74) for asthma, and 1.25 (95\% CI: 1.13, 1.38) for GERD.CONCLUSIONS: WTC general responders have a substantial burden of asthma and GERD, with higher incidence in women. Am. J. Ind. Med. 59:815-822, 2016.",

keywords = "9/11, asthma, GERD, World Trade Center",

author = "Jieying Jiang and Nikolina Icitovic and Crane, \{Michael A.\} and Dasaro, \{Christopher R.\} and Kaplan, \{Julia R.\} and Lucchini, \{Roberto G.\} and Luft, \{Benjamin J.\} and Moline, \{Jacqueline M.\} and Lakshmi Pendem and Moshe Shapiro and Udasin, \{Iris G.\} and Todd, \{Andrew C.\} and Teitelbaum, \{Susan L.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Wiley Periodicals, Inc.",

year = "2016",

month = sep,

day = "1",

doi = "10.1002/ajim.22634",

language = "English",

volume = "59",

pages = "815--822",

journal = "American Journal of Industrial Medicine",

issn = "0271-3586",

number = "9",

}

Jiang, J, Icitovic, N, Crane, MA, Dasaro, CR, Kaplan, JR, Lucchini, RG, Luft, BJ, Moline, JM, Pendem, L, Shapiro, M, Udasin, IG, Todd, AC & Teitelbaum, SL 2016, 'Sex differences in asthma and gastroesophageal reflux disease incidence among the World Trade Center Health Program General Responder Cohort', American Journal of Industrial Medicine, vol. 59, no. 9, pp. 815-822. https://doi.org/10.1002/ajim.22634

TY - JOUR

T1 - Sex differences in asthma and gastroesophageal reflux disease incidence among the World Trade Center Health Program General Responder Cohort

AU - Jiang, Jieying

AU - Icitovic, Nikolina

AU - Crane, Michael A.

AU - Dasaro, Christopher R.

AU - Kaplan, Julia R.

AU - Lucchini, Roberto G.

AU - Luft, Benjamin J.

AU - Moline, Jacqueline M.

AU - Pendem, Lakshmi

AU - Shapiro, Moshe

AU - Udasin, Iris G.

AU - Todd, Andrew C.

AU - Teitelbaum, Susan L.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - BACKGROUND: Asthma and gastroesophageal reflux disease (GERD) are two common conditions among the responders to the WTC attacks. This study examined whether the cumulative incidence rates of asthma and GERD differed by sex among 24,022 and 23,557 WTC responders, respectively.METHODS: Cox proportional hazards regression was used to examine the sex difference in the rate of onset of physician-diagnosed asthma or GERD, from 9/12/2001 through 12/31/2015.RESULTS: The cumulative incidence of asthma reached 23% for women and 17% for men by the end of 2015, and the cumulative incidence of GERD reached 45% for women and 38% for men. Comparing women to men, the hazard ratio was 1.48 (95% confidence interval (CI): 1.27, 1.74) for asthma, and 1.25 (95% CI: 1.13, 1.38) for GERD.CONCLUSIONS: WTC general responders have a substantial burden of asthma and GERD, with higher incidence in women. Am. J. Ind. Med. 59:815-822, 2016.

AB - BACKGROUND: Asthma and gastroesophageal reflux disease (GERD) are two common conditions among the responders to the WTC attacks. This study examined whether the cumulative incidence rates of asthma and GERD differed by sex among 24,022 and 23,557 WTC responders, respectively.METHODS: Cox proportional hazards regression was used to examine the sex difference in the rate of onset of physician-diagnosed asthma or GERD, from 9/12/2001 through 12/31/2015.RESULTS: The cumulative incidence of asthma reached 23% for women and 17% for men by the end of 2015, and the cumulative incidence of GERD reached 45% for women and 38% for men. Comparing women to men, the hazard ratio was 1.48 (95% confidence interval (CI): 1.27, 1.74) for asthma, and 1.25 (95% CI: 1.13, 1.38) for GERD.CONCLUSIONS: WTC general responders have a substantial burden of asthma and GERD, with higher incidence in women. Am. J. Ind. Med. 59:815-822, 2016.

KW - 9/11

KW - asthma

KW - GERD

KW - World Trade Center

UR - https://www.scopus.com/pages/publications/84984860922

U2 - 10.1002/ajim.22634

DO - 10.1002/ajim.22634

M3 - Article

C2 - 27424876

AN - SCOPUS:84984860922

SN - 0271-3586

VL - 59

SP - 815

EP - 822

JO - American Journal of Industrial Medicine

JF - American Journal of Industrial Medicine

IS - 9

ER -

Sex differences in asthma and gastroesophageal reflux disease incidence among the World Trade Center Health Program General Responder Cohort

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this