TY - JOUR
T1 - Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses
AU - Posttraumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium
AU - Shen, Jie
AU - Valentim, Wander
AU - Friligkou, Eleni
AU - Overstreet, Cassie
AU - Choi, Karmel W.
AU - Koller, Dora
AU - O’Donnell, Christopher J.
AU - Stein, Murray B.
AU - Gelernter, Joel
AU - Koenen, Karestan C.
AU - Ressler, Kerry J.
AU - Zwart, John Anker
AU - Zoellner, Lori A.
AU - Zhao, Hongyu
AU - Zervas, Mark
AU - Zai, Gwyneth C.
AU - Zai, Clement C.
AU - Young, Keith A.
AU - Young, Ross Mc D.
AU - Yehuda, Rachel
AU - Xiong, Ying
AU - Xia, Yan
AU - Wolf, Christiane
AU - Wolf, Erika J.
AU - Winternitz, Sherry
AU - Winsvold, Bendik S.
AU - Williamson, Douglas E.
AU - Williams, Michelle A.
AU - Werge, Thomas
AU - Wendt, Frank R.
AU - Weber, Heike
AU - Waszczuk, Monika
AU - Wang, Yunpeng
AU - Wang, Zhewu
AU - Voisey, Joanne
AU - Vinkers, Christiaan H.
AU - Vermetten, Eric
AU - van Rooij, Sanne J.H.
AU - Van Hooff, Miranda
AU - van den Heuvel, Leigh Luella
AU - Valdimarsdóttir, Unnur
AU - Ursano, Robert J.
AU - Uddin, Monica
AU - Trapido, Edward
AU - Tiwari, Arun K.
AU - Sampson, Laura
AU - Luft, Benjamin J.
AU - Kuan, Pei Fen
AU - Kotov, Roman
AU - Clouston, Sean A.P.
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life’s Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions. Potentially shared causal variants between post-traumatic stress disorder and 17 cardiovascular conditions were observed in 11 regions. Subsequent observational analysis in AllofUS cohort showed post-traumatic stress disorder is associated with 13 diagnoses even after accounting for socioeconomic factors and depression. Genetically regulated proteome expression in brain and blood tissues identified 33 blood and 122 brain genes shared between the two conditions, revealing neuronal, immune, metabolic, and calcium-related mechanisms, with several genes as targets for existing drugs. These findings exhibit shared risk loci and genes are involved in tissue-specific mechanisms.
AB - Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life’s Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions. Potentially shared causal variants between post-traumatic stress disorder and 17 cardiovascular conditions were observed in 11 regions. Subsequent observational analysis in AllofUS cohort showed post-traumatic stress disorder is associated with 13 diagnoses even after accounting for socioeconomic factors and depression. Genetically regulated proteome expression in brain and blood tissues identified 33 blood and 122 brain genes shared between the two conditions, revealing neuronal, immune, metabolic, and calcium-related mechanisms, with several genes as targets for existing drugs. These findings exhibit shared risk loci and genes are involved in tissue-specific mechanisms.
UR - https://www.scopus.com/pages/publications/105010289456
U2 - 10.1038/s41467-025-60487-w
DO - 10.1038/s41467-025-60487-w
M3 - Article
C2 - 40595462
AN - SCOPUS:105010289456
SN - 2041-1723
VL - 16
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5631
ER -