Side effects of desipramine and age

Introduction: The treatment response of children and adolescents to tricyclic antidepressants differs from that of adults. Few data exist on the impact of age on side effects. This study compares desipramine-associated side effects in children, adolescents, and adults. Methods: Data from three trials of desipramine were combined to produce a sample of 148 subjects, aged 7 to 66 years. Pulse and blood pressure were measured at baseline and while participants were receiving desipramine. Side effects were rated by a clinician. For data analysis, subjects were divided into two groups, younger patients (18 and younger) and older patients (19 and older). Group means of side effect ratings and vital signs were compared. Results were also analyzed covarying for plasma levels of desipramine. Results: There were significant differences between younger and older patients in pulse and blood pressure at baseline, on desipramine, and in changes in vital signs between baseline and medicated states. Younger patients had significantly lower mean ratings for constipation and dry mouth. Discussion: Treatment with desipramine results in differing degrees of subjective side effects and changes in vital signs across the life cycle. Physicians should not assume that side effects experienced by children and adolescents are identical to those experienced by adults.