Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition

Brian A. Kinney; Arwa Al Anber; Richard H. Row; Yu Jung Tseng; Maxwell D. Weidmann; Holger Knaut; Benjamin L. Martin

doi:10.1016/j.celrep.2020.108311

Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition

Brian A. Kinney
, Arwa Al Anber
, Richard H. Row
, Yu Jung Tseng
, Maxwell D. Weidmann
, Holger Knaut
, Benjamin L. Martin

Biochemistry and Cell Biology

Stony Brook University
New York University

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

During embryonic development, the right tissue types must form in the proper location. Kinney et al. show that a developmental checkpoint functions during mesoderm induction, ensuring that Sox2-expressing cells do not migrate into the mesoderm. This checkpoint is critical for preventing ectopic spinal cord from forming in place of mesoderm.

Original language	English
Article number	108311
Journal	Cell Reports
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2020.108311
State	Published - Oct 27 2020

Keywords

canonical Wnt signaling
mesoderm
neuromesodermal progenitors
somite
sox2
spinal cord
tbx16
zebrafish

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10.1016/j.celrep.2020.108311

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title = "Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition",

abstract = "During embryonic development, the right tissue types must form in the proper location. Kinney et al. show that a developmental checkpoint functions during mesoderm induction, ensuring that Sox2-expressing cells do not migrate into the mesoderm. This checkpoint is critical for preventing ectopic spinal cord from forming in place of mesoderm.",

keywords = "canonical Wnt signaling, mesoderm, neuromesodermal progenitors, somite, sox2, spinal cord, tbx16, zebrafish",

author = "Kinney, \{Brian A.\} and \{Al Anber\}, Arwa and Row, \{Richard H.\} and Tseng, \{Yu Jung\} and Weidmann, \{Maxwell D.\} and Holger Knaut and Martin, \{Benjamin L.\}",

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AU - Kinney, Brian A.

AU - Al Anber, Arwa

AU - Row, Richard H.

AU - Tseng, Yu Jung

AU - Weidmann, Maxwell D.

AU - Knaut, Holger

AU - Martin, Benjamin L.

PY - 2020/10/27

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KW - canonical Wnt signaling

KW - mesoderm

KW - neuromesodermal progenitors

KW - somite

KW - sox2

KW - spinal cord

KW - tbx16

KW - zebrafish

UR - https://www.scopus.com/pages/publications/85094320931

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DO - 10.1016/j.celrep.2020.108311

M3 - Article

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JF - Cell Reports

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ER -

Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition

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Keywords

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