Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

Stephanie Z. Xie; Laura Garcia-Prat; Veronique Voisin; Robin Ferrari; Olga I. Gan; Elvin Wagenblast; Kerstin B. Kaufmann; Andy G.X. Zeng; Shin ichiro Takayanagi; Ishita Patel; Esther K. Lee; Joseph Jargstorf; Gareth Holmes; Guy Romm; Kristele Pan; Michelle Shoong; Aditi Vedi; Chiara Luberto; Mark D. Minden; Gary D. Bader; Elisa Laurenti; John E. Dick

doi:10.1016/j.stem.2019.09.008

Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

Stephanie Z. Xie
, Laura Garcia-Prat
, Veronique Voisin
, Robin Ferrari
, Olga I. Gan
, Elvin Wagenblast
, Kerstin B. Kaufmann
, Andy G.X. Zeng
, Shin ichiro Takayanagi
, Ishita Patel
, Esther K. Lee
, Joseph Jargstorf
, Gareth Holmes
, Guy Romm
, Kristele Pan
, Michelle Shoong
, Aditi Vedi
, Chiara Luberto
, Mark D. Minden
, Gary D. Bader

Elisa Laurenti, John E. Dick

Physiology and Biophysics

Princess Margaret Cancer Centre
University of Toronto
Kirin Holdings Co., Ltd.
University of Cambridge
Centre of Excellence on Aging and Chronic Diseases of McGill Integrated University Health Network

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Lipid metabolism is distinctly regulated in human hematopoietic stem cells (HSCs) versus progenitors. Xie et al. profiled the sphingolipidome in human cord blood and show that modulating sphingolipids during the transition from quiescence to cellular activation in ex vivo culture induced proteostatic cellular stress programs to maintain HSC self-renewal.

Original language	English
Pages (from-to)	639-653.e7
Journal	Cell Stem Cell
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2019.09.008
State	Published - Nov 7 2019

Keywords

autophagy
DEGS1
fenretinide
hematopoietic stem cell
lipidomics
sphingolipid metabolism
StemRegenin-1
UM171
umbilical cord blood
unfolded protein response

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10.1016/j.stem.2019.09.008

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Xie, S. Z., Garcia-Prat, L., Voisin, V., Ferrari, R., Gan, O. I., Wagenblast, E., Kaufmann, K. B., Zeng, A. G. X., Takayanagi, S. I., Patel, I., Lee, E. K., Jargstorf, J., Holmes, G., Romm, G., Pan, K., Shoong, M., Vedi, A., Luberto, C., Minden, M. D., ... Dick, J. E. (2019). Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal. Cell Stem Cell, 25(5), 639-653.e7. https://doi.org/10.1016/j.stem.2019.09.008

@article{29734f4473d741d995ab4530657b723a,

title = "Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal",

abstract = "Lipid metabolism is distinctly regulated in human hematopoietic stem cells (HSCs) versus progenitors. Xie et al. profiled the sphingolipidome in human cord blood and show that modulating sphingolipids during the transition from quiescence to cellular activation in ex vivo culture induced proteostatic cellular stress programs to maintain HSC self-renewal.",

keywords = "autophagy, DEGS1, fenretinide, hematopoietic stem cell, lipidomics, sphingolipid metabolism, StemRegenin-1, UM171, umbilical cord blood, unfolded protein response",

author = "Xie, \{Stephanie Z.\} and Laura Garcia-Prat and Veronique Voisin and Robin Ferrari and Gan, \{Olga I.\} and Elvin Wagenblast and Kaufmann, \{Kerstin B.\} and Zeng, \{Andy G.X.\} and Takayanagi, \{Shin ichiro\} and Ishita Patel and Lee, \{Esther K.\} and Joseph Jargstorf and Gareth Holmes and Guy Romm and Kristele Pan and Michelle Shoong and Aditi Vedi and Chiara Luberto and Minden, \{Mark D.\} and Bader, \{Gary D.\} and Elisa Laurenti and Dick, \{John E.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = nov,

day = "7",

doi = "10.1016/j.stem.2019.09.008",

language = "English",

volume = "25",

pages = "639--653.e7",

journal = "Cell Stem Cell",

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Xie, SZ, Garcia-Prat, L, Voisin, V, Ferrari, R, Gan, OI, Wagenblast, E, Kaufmann, KB, Zeng, AGX, Takayanagi, SI, Patel, I, Lee, EK, Jargstorf, J, Holmes, G, Romm, G, Pan, K, Shoong, M, Vedi, A, Luberto, C, Minden, MD, Bader, GD, Laurenti, E & Dick, JE 2019, 'Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal', Cell Stem Cell, vol. 25, no. 5, pp. 639-653.e7. https://doi.org/10.1016/j.stem.2019.09.008

TY - JOUR

T1 - Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

AU - Xie, Stephanie Z.

AU - Garcia-Prat, Laura

AU - Voisin, Veronique

AU - Ferrari, Robin

AU - Gan, Olga I.

AU - Wagenblast, Elvin

AU - Kaufmann, Kerstin B.

AU - Zeng, Andy G.X.

AU - Takayanagi, Shin ichiro

AU - Patel, Ishita

AU - Lee, Esther K.

AU - Jargstorf, Joseph

AU - Holmes, Gareth

AU - Romm, Guy

AU - Pan, Kristele

AU - Shoong, Michelle

AU - Vedi, Aditi

AU - Luberto, Chiara

AU - Minden, Mark D.

AU - Bader, Gary D.

AU - Laurenti, Elisa

AU - Dick, John E.

PY - 2019/11/7

Y1 - 2019/11/7

N2 - Lipid metabolism is distinctly regulated in human hematopoietic stem cells (HSCs) versus progenitors. Xie et al. profiled the sphingolipidome in human cord blood and show that modulating sphingolipids during the transition from quiescence to cellular activation in ex vivo culture induced proteostatic cellular stress programs to maintain HSC self-renewal.

AB - Lipid metabolism is distinctly regulated in human hematopoietic stem cells (HSCs) versus progenitors. Xie et al. profiled the sphingolipidome in human cord blood and show that modulating sphingolipids during the transition from quiescence to cellular activation in ex vivo culture induced proteostatic cellular stress programs to maintain HSC self-renewal.

KW - autophagy

KW - DEGS1

KW - fenretinide

KW - hematopoietic stem cell

KW - lipidomics

KW - sphingolipid metabolism

KW - StemRegenin-1

KW - UM171

KW - umbilical cord blood

KW - unfolded protein response

UR - https://www.scopus.com/pages/publications/85074302761

U2 - 10.1016/j.stem.2019.09.008

DO - 10.1016/j.stem.2019.09.008

M3 - Article

C2 - 31631013

AN - SCOPUS:85074302761

SN - 1934-5909

VL - 25

SP - 639-653.e7

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 5

ER -

Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

Abstract

Keywords

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