STAT3 Revs up the powerhouse

Nancy C. Reich

doi:10.1126/scisignal.290pe61

STAT3 Revs up the powerhouse

Nancy C. Reich

Microbiology and Immunology

Research output: Contribution to journal › Short survey › peer-review

46 Scopus citations

Abstract

Tyrosine phosphorylation of signal transducers and activators of transcription (STATs) promotes their dimerization and ability to bind target genes in the nucleus. However, evidence shows that one member of the STAT family, STAT3, has an additional property independent of its classical role in the nucleus. STAT3 modifed by serine phosphorylation augmented oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras.

Original language	English
Pages (from-to)	pe61
Journal	Science Signaling
Volume	2
Issue number	90
DOIs	https://doi.org/10.1126/scisignal.290pe61
State	Published - Sep 29 2009

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title = "STAT3 Revs up the powerhouse",

abstract = "Tyrosine phosphorylation of signal transducers and activators of transcription (STATs) promotes their dimerization and ability to bind target genes in the nucleus. However, evidence shows that one member of the STAT family, STAT3, has an additional property independent of its classical role in the nucleus. STAT3 modifed by serine phosphorylation augmented oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras.",

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AB - Tyrosine phosphorylation of signal transducers and activators of transcription (STATs) promotes their dimerization and ability to bind target genes in the nucleus. However, evidence shows that one member of the STAT family, STAT3, has an additional property independent of its classical role in the nucleus. STAT3 modifed by serine phosphorylation augmented oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras.

UR - https://www.scopus.com/pages/publications/73349102809

U2 - 10.1126/scisignal.290pe61

DO - 10.1126/scisignal.290pe61

M3 - Short survey

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SP - pe61

JO - Science Signaling

JF - Science Signaling

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ER -

STAT3 Revs up the powerhouse

Abstract

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