Stem Cell Mobilization with Cyclophosphamide Overcomes the Suppressive Effect of Lenalidomide Therapy on Stem Cell Collection in Multiple Myeloma

Tomer Mark; Jessica Stern; Jessica R. Furst; David Jayabalan; Faiza Zafar; April LaRow; Roger N. Pearse; John Harpel; Tsiporah Shore; Michael W. Schuster; John P. Leonard; Paul J. Christos; Morton Coleman; Ruben Niesvizky

doi:10.1016/j.bbmt.2008.04.008

Stem Cell Mobilization with Cyclophosphamide Overcomes the Suppressive Effect of Lenalidomide Therapy on Stem Cell Collection in Multiple Myeloma

Tomer Mark
, Jessica Stern
, Jessica R. Furst
, David Jayabalan
, Faiza Zafar
, April LaRow
, Roger N. Pearse
, John Harpel
, Tsiporah Shore
, Michael W. Schuster
, John P. Leonard
, Paul J. Christos
, Morton Coleman
, Ruben Niesvizky

Medical Oncology

Cornell University

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

A total of 28 treatment-naïve patients with stage II or III multiple myeloma (MM) were treated with the combination of clarithromycin, lenalidomide, and dexamethasone (BiRD). Stem cells were collected following granulocyte-colony stimulating factor (G-CSF) or cyclophosphamide (Cy) plus G-CSF mobilization at maximum response. Sufficient stem cells for 2 autologous stem cell transplants were collected from all patients mobilized with Cy plus G-CSF, versus 33% mobilized with G-CSF alone (P < .0001). The duration of prior lenalidomide therapy did not correlate with success of stem cell harvests (P = .91). In conclusion, Cy can be added to G-CSF for stem cell mobilization to successfully overcome the suppressive effect of prior treatment with lenalidomide.

Original language	English
Pages (from-to)	795-798
Number of pages	4
Journal	Biology of Blood and Marrow Transplantation
Volume	14
Issue number	7
DOIs	https://doi.org/10.1016/j.bbmt.2008.04.008
State	Published - Jul 2008

Keywords

Autologous stem cell transplantation
Cyclophosphamide
Lenalidomide
Multiple myeloma
Stem cell mobilization

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10.1016/j.bbmt.2008.04.008

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Mark, T., Stern, J., Furst, J. R., Jayabalan, D., Zafar, F., LaRow, A., Pearse, R. N., Harpel, J., Shore, T., Schuster, M. W., Leonard, J. P., Christos, P. J., Coleman, M., & Niesvizky, R. (2008). Stem Cell Mobilization with Cyclophosphamide Overcomes the Suppressive Effect of Lenalidomide Therapy on Stem Cell Collection in Multiple Myeloma. Biology of Blood and Marrow Transplantation, 14(7), 795-798. https://doi.org/10.1016/j.bbmt.2008.04.008

@article{d56aa1e3d9ba4c228a3ed4feb93c34b3,

title = "Stem Cell Mobilization with Cyclophosphamide Overcomes the Suppressive Effect of Lenalidomide Therapy on Stem Cell Collection in Multiple Myeloma",

abstract = "A total of 28 treatment-na{\"i}ve patients with stage II or III multiple myeloma (MM) were treated with the combination of clarithromycin, lenalidomide, and dexamethasone (BiRD). Stem cells were collected following granulocyte-colony stimulating factor (G-CSF) or cyclophosphamide (Cy) plus G-CSF mobilization at maximum response. Sufficient stem cells for 2 autologous stem cell transplants were collected from all patients mobilized with Cy plus G-CSF, versus 33\% mobilized with G-CSF alone (P < .0001). The duration of prior lenalidomide therapy did not correlate with success of stem cell harvests (P = .91). In conclusion, Cy can be added to G-CSF for stem cell mobilization to successfully overcome the suppressive effect of prior treatment with lenalidomide.",

keywords = "Autologous stem cell transplantation, Cyclophosphamide, Lenalidomide, Multiple myeloma, Stem cell mobilization",

author = "Tomer Mark and Jessica Stern and Furst, \{Jessica R.\} and David Jayabalan and Faiza Zafar and April LaRow and Pearse, \{Roger N.\} and John Harpel and Tsiporah Shore and Schuster, \{Michael W.\} and Leonard, \{John P.\} and Christos, \{Paul J.\} and Morton Coleman and Ruben Niesvizky",

year = "2008",

month = jul,

doi = "10.1016/j.bbmt.2008.04.008",

language = "English",

volume = "14",

pages = "795--798",

journal = "Biology of Blood and Marrow Transplantation",

issn = "1083-8791",

number = "7",

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Mark, T, Stern, J, Furst, JR, Jayabalan, D, Zafar, F, LaRow, A, Pearse, RN, Harpel, J, Shore, T, Schuster, MW, Leonard, JP, Christos, PJ, Coleman, M & Niesvizky, R 2008, 'Stem Cell Mobilization with Cyclophosphamide Overcomes the Suppressive Effect of Lenalidomide Therapy on Stem Cell Collection in Multiple Myeloma', Biology of Blood and Marrow Transplantation, vol. 14, no. 7, pp. 795-798. https://doi.org/10.1016/j.bbmt.2008.04.008

TY - JOUR

T1 - Stem Cell Mobilization with Cyclophosphamide Overcomes the Suppressive Effect of Lenalidomide Therapy on Stem Cell Collection in Multiple Myeloma

AU - Mark, Tomer

AU - Stern, Jessica

AU - Furst, Jessica R.

AU - Jayabalan, David

AU - Zafar, Faiza

AU - LaRow, April

AU - Pearse, Roger N.

AU - Harpel, John

AU - Shore, Tsiporah

AU - Schuster, Michael W.

AU - Leonard, John P.

AU - Christos, Paul J.

AU - Coleman, Morton

AU - Niesvizky, Ruben

PY - 2008/7

Y1 - 2008/7

N2 - A total of 28 treatment-naïve patients with stage II or III multiple myeloma (MM) were treated with the combination of clarithromycin, lenalidomide, and dexamethasone (BiRD). Stem cells were collected following granulocyte-colony stimulating factor (G-CSF) or cyclophosphamide (Cy) plus G-CSF mobilization at maximum response. Sufficient stem cells for 2 autologous stem cell transplants were collected from all patients mobilized with Cy plus G-CSF, versus 33% mobilized with G-CSF alone (P < .0001). The duration of prior lenalidomide therapy did not correlate with success of stem cell harvests (P = .91). In conclusion, Cy can be added to G-CSF for stem cell mobilization to successfully overcome the suppressive effect of prior treatment with lenalidomide.

AB - A total of 28 treatment-naïve patients with stage II or III multiple myeloma (MM) were treated with the combination of clarithromycin, lenalidomide, and dexamethasone (BiRD). Stem cells were collected following granulocyte-colony stimulating factor (G-CSF) or cyclophosphamide (Cy) plus G-CSF mobilization at maximum response. Sufficient stem cells for 2 autologous stem cell transplants were collected from all patients mobilized with Cy plus G-CSF, versus 33% mobilized with G-CSF alone (P < .0001). The duration of prior lenalidomide therapy did not correlate with success of stem cell harvests (P = .91). In conclusion, Cy can be added to G-CSF for stem cell mobilization to successfully overcome the suppressive effect of prior treatment with lenalidomide.

KW - Autologous stem cell transplantation

KW - Cyclophosphamide

KW - Lenalidomide

KW - Multiple myeloma

KW - Stem cell mobilization

UR - https://www.scopus.com/pages/publications/44649202066

U2 - 10.1016/j.bbmt.2008.04.008

DO - 10.1016/j.bbmt.2008.04.008

M3 - Article

C2 - 18541199

AN - SCOPUS:44649202066

SN - 1083-8791

VL - 14

SP - 795

EP - 798

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

IS - 7

ER -

Stem Cell Mobilization with Cyclophosphamide Overcomes the Suppressive Effect of Lenalidomide Therapy on Stem Cell Collection in Multiple Myeloma

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