Structure-activity relationships of double-strand RGD peptides as GPIIb/IIIa receptor antogonists

Iwao Ojima; Qing Dong; Masakatsu Eguchi; Young im Oh; Clare M. Amann; Barry S. Coller

doi:10.1016/S0960-894X(00)80374-1

Structure-activity relationships of double-strand RGD peptides as GPIIb/IIIa receptor antogonists

Iwao Ojima
, Qing Dong
, Masakatsu Eguchi
, Young im Oh
, Clare M. Amann
, Barry S. Coller

Chemistry

Stony Brook University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A series of new double-strand RGD peptides are synthesized and their inhibitory activities evaluated for platelet aggregation. Substantial improvement in activity is observed with these novel RGD peptides in comparison with single-strand RGD peptides. The structure-activity relationships of these double-strand RGD peptides are discussed.

Original language	English
Pages (from-to)	1749-1754
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(00)80374-1
State	Published - Jul 21 1994

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10.1016/S0960-894X(00)80374-1

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@article{87a5fd21112440beb51e7f69ca6c48af,

title = "Structure-activity relationships of double-strand RGD peptides as GPIIb/IIIa receptor antogonists",

abstract = "A series of new double-strand RGD peptides are synthesized and their inhibitory activities evaluated for platelet aggregation. Substantial improvement in activity is observed with these novel RGD peptides in comparison with single-strand RGD peptides. The structure-activity relationships of these double-strand RGD peptides are discussed.",

author = "Iwao Ojima and Qing Dong and Masakatsu Eguchi and Oh, \{Young im\} and Amann, \{Clare M.\} and Coller, \{Barry S.\}",

year = "1994",

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day = "21",

doi = "10.1016/S0960-894X(00)80374-1",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Structure-activity relationships of double-strand RGD peptides as GPIIb/IIIa receptor antogonists

AU - Ojima, Iwao

AU - Dong, Qing

AU - Eguchi, Masakatsu

AU - Oh, Young im

AU - Amann, Clare M.

AU - Coller, Barry S.

PY - 1994/7/21

Y1 - 1994/7/21

N2 - A series of new double-strand RGD peptides are synthesized and their inhibitory activities evaluated for platelet aggregation. Substantial improvement in activity is observed with these novel RGD peptides in comparison with single-strand RGD peptides. The structure-activity relationships of these double-strand RGD peptides are discussed.

AB - A series of new double-strand RGD peptides are synthesized and their inhibitory activities evaluated for platelet aggregation. Substantial improvement in activity is observed with these novel RGD peptides in comparison with single-strand RGD peptides. The structure-activity relationships of these double-strand RGD peptides are discussed.

UR - https://www.scopus.com/pages/publications/0028106561

U2 - 10.1016/S0960-894X(00)80374-1

DO - 10.1016/S0960-894X(00)80374-1

M3 - Article

AN - SCOPUS:0028106561

SN - 0960-894X

VL - 4

SP - 1749

EP - 1754

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Structure-activity relationships of double-strand RGD peptides as GPIIb/IIIa receptor antogonists

Abstract

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