Skip to main navigation Skip to search Skip to main content

Syndecan-3: A Signaling Conductor in the Musculoskeletal System

  • F. K. Jones
  • , O. Kehoe
  • , A. Daroszewska
  • , R. J. van’t Hof
  • , A. Pisconti
  • Stony Brook University
  • Keele University
  • University of Liverpool
  • Liverpool University Hospitals NHS Foundation Trust

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Syndecan-3 is a transmembrane proteoglycan, the largest of the four syndecan family members and the most mysterious. To date, the number of published studies involving syndecan-3 is only a small fraction of the number of studies involving the other subfamily member syndecan-1, yet, these few studies on syndecan-3 cover a whole range of biological functions and phenotypes suggesting that syndecan-3 might be the most eclectic and intereting of the four syndecans. In this review, we focus on what is currently known about the role of syndecan-3 in the musculoskeletal system, from development to aging, including regeneration and disease. We also briefly refer to known syndecan-3 functions in other tissues and systems in an attempt to summarize the most up-to-date knowledge while also instilling curiosity about this extraordinary biomolecule and, hopefully, inspiring more research into its biochemistry and biological functions.

Original languageEnglish
Title of host publicationBiology of Extracellular Matrix
PublisherSpringer Science and Business Media Deutschland GmbH
Pages153-177
Number of pages25
DOIs
StatePublished - 2021

Publication series

NameBiology of Extracellular Matrix
Volume9
ISSN (Print)0887-3224
ISSN (Electronic)2191-1959

Keywords

  • Bone
  • Cartilage
  • Development
  • Muscle
  • Proteoglycans
  • Regeneration
  • Stem cells
  • Syndecan-3

Fingerprint

Dive into the research topics of 'Syndecan-3: A Signaling Conductor in the Musculoskeletal System'. Together they form a unique fingerprint.

Cite this