Synthesis and biological activity of 14-hydroxydocetaxel

Iwao Ojima; Ivana Fenoglio; Young Hoom Park; Paula Pera; Ralph J. Bernacki

doi:10.1016/S0960-894X(01)80568-0

Synthesis and biological activity of 14-hydroxydocetaxel

Iwao Ojima
, Ivana Fenoglio
, Young Hoom Park
, Paula Pera
, Ralph J. Bernacki

Chemistry

Stony Brook University
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

New taxoids, 14β-hydroxydicetaxek abd uts 1m14-acetonide, are synthesized from 14β-hydroxy-10-deacetylbaccatin III in good yields. The cytotoxicity of the new taxoids are evaluated against different human tumor cell lines and their ability to inhibit the microtubules disassembly examined. 14β-hydroxydocetaxel shows very strong cytotoxicity, especially against A549 human non-small cell lung cancer cell line (IC₅₀ = 0.8 nM).

Original language	English
Pages (from-to)	1571-1576
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(01)80568-0
State	Published - Jul 7 1994

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title = "Synthesis and biological activity of 14-hydroxydocetaxel",

abstract = "New taxoids, 14β-hydroxydicetaxek abd uts 1m14-acetonide, are synthesized from 14β-hydroxy-10-deacetylbaccatin III in good yields. The cytotoxicity of the new taxoids are evaluated against different human tumor cell lines and their ability to inhibit the microtubules disassembly examined. 14β-hydroxydocetaxel shows very strong cytotoxicity, especially against A549 human non-small cell lung cancer cell line (IC50 = 0.8 nM).",

author = "Iwao Ojima and Ivana Fenoglio and Park, \{Young Hoom\} and Paula Pera and Bernacki, \{Ralph J.\}",

year = "1994",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Synthesis and biological activity of 14-hydroxydocetaxel

AU - Ojima, Iwao

AU - Fenoglio, Ivana

AU - Park, Young Hoom

AU - Pera, Paula

AU - Bernacki, Ralph J.

PY - 1994/7/7

Y1 - 1994/7/7

N2 - New taxoids, 14β-hydroxydicetaxek abd uts 1m14-acetonide, are synthesized from 14β-hydroxy-10-deacetylbaccatin III in good yields. The cytotoxicity of the new taxoids are evaluated against different human tumor cell lines and their ability to inhibit the microtubules disassembly examined. 14β-hydroxydocetaxel shows very strong cytotoxicity, especially against A549 human non-small cell lung cancer cell line (IC50 = 0.8 nM).

AB - New taxoids, 14β-hydroxydicetaxek abd uts 1m14-acetonide, are synthesized from 14β-hydroxy-10-deacetylbaccatin III in good yields. The cytotoxicity of the new taxoids are evaluated against different human tumor cell lines and their ability to inhibit the microtubules disassembly examined. 14β-hydroxydocetaxel shows very strong cytotoxicity, especially against A549 human non-small cell lung cancer cell line (IC50 = 0.8 nM).

UR - https://www.scopus.com/pages/publications/0028343398

U2 - 10.1016/S0960-894X(01)80568-0

DO - 10.1016/S0960-894X(01)80568-0

M3 - Article

AN - SCOPUS:0028343398

SN - 0960-894X

VL - 4

SP - 1571

EP - 1576

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Synthesis and biological activity of 14-hydroxydocetaxel

Abstract

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