Synthesis of [1–11C]Butanol via a facile solid phase extraction protocol

Nicole N. Waterhouse; Paresh J. Kothari; Marybeth Dooley; Bao Hu; Mony J. de Leon; John Babich; Wenchao Qu

doi:10.1016/j.apradiso.2020.109078

Synthesis of [1–¹¹C]Butanol via a facile solid phase extraction protocol

Nicole N. Waterhouse
, Paresh J. Kothari
, Marybeth Dooley
, Bao Hu
, Mony J. de Leon
, John Babich
, Wenchao Qu

Psychiatry

Citigroup
Cornell University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A facile synthesis method for the preparation of [1–¹¹C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1–¹¹C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements.

Original language	English
Article number	109078
Journal	Applied Radiation and Isotopes
Volume	159
DOIs	https://doi.org/10.1016/j.apradiso.2020.109078
State	Published - May 2020

Keywords

Cerebral blood flow
Grignard reagent
Solid phase extraction
[1–C]Butanol

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10.1016/j.apradiso.2020.109078

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title = "Synthesis of [1–11C]Butanol via a facile solid phase extraction protocol",

abstract = "A facile synthesis method for the preparation of [1–11C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1–11C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements.",

keywords = "Cerebral blood flow, Grignard reagent, Solid phase extraction, [1–C]Butanol",

author = "Waterhouse, \{Nicole N.\} and Kothari, \{Paresh J.\} and Marybeth Dooley and Bao Hu and \{de Leon\}, \{Mony J.\} and John Babich and Wenchao Qu",

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year = "2020",

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doi = "10.1016/j.apradiso.2020.109078",

language = "English",

volume = "159",

journal = "Applied Radiation and Isotopes",

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T1 - Synthesis of [1–11C]Butanol via a facile solid phase extraction protocol

AU - Waterhouse, Nicole N.

AU - Kothari, Paresh J.

AU - Dooley, Marybeth

AU - Hu, Bao

AU - de Leon, Mony J.

AU - Babich, John

AU - Qu, Wenchao

PY - 2020/5

Y1 - 2020/5

N2 - A facile synthesis method for the preparation of [1–11C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1–11C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements.

AB - A facile synthesis method for the preparation of [1–11C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1–11C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements.

KW - Cerebral blood flow

KW - Grignard reagent

KW - Solid phase extraction

KW - [1–C]Butanol

UR - https://www.scopus.com/pages/publications/85079345804

U2 - 10.1016/j.apradiso.2020.109078

DO - 10.1016/j.apradiso.2020.109078

M3 - Article

C2 - 32068145

AN - SCOPUS:85079345804

SN - 0969-8043

VL - 159

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 109078

ER -

Synthesis of [1–¹¹C]Butanol via a facile solid phase extraction protocol

Abstract

Keywords

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