Synthesis of 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine and its use as a probe to study DNA-base excision by mutY enzyme

Chamakura V. Varaprasad; Nickolai Bulychev; Arthur P. Grollman; Francis Johnson

doi:10.1016/0040-4039(95)02069-1

Synthesis of 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine and its use as a probe to study DNA-base excision by mutY enzyme

Chamakura V. Varaprasad
, Nickolai Bulychev
, Arthur P. Grollman
, Francis Johnson

Pharmacological Sciences

Stony Brook University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A 23mer oligomer containing 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine (1) has been synthesized from 2′-deoxyguanosine. The activity of MutY protein toward this and a related oligomer containing 8-methoxy-dG has been studied.

Original language	English
Pages (from-to)	9-12
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/0040-4039(95)02069-1
State	Published - Jan 1 1996

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title = "Synthesis of 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine and its use as a probe to study DNA-base excision by mutY enzyme",

abstract = "A 23mer oligomer containing 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine (1) has been synthesized from 2′-deoxyguanosine. The activity of MutY protein toward this and a related oligomer containing 8-methoxy-dG has been studied.",

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AU - Varaprasad, Chamakura V.

AU - Bulychev, Nickolai

AU - Grollman, Arthur P.

AU - Johnson, Francis

PY - 1996/1/1

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N2 - A 23mer oligomer containing 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine (1) has been synthesized from 2′-deoxyguanosine. The activity of MutY protein toward this and a related oligomer containing 8-methoxy-dG has been studied.

AB - A 23mer oligomer containing 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine (1) has been synthesized from 2′-deoxyguanosine. The activity of MutY protein toward this and a related oligomer containing 8-methoxy-dG has been studied.

UR - https://www.scopus.com/pages/publications/0030049828

U2 - 10.1016/0040-4039(95)02069-1

DO - 10.1016/0040-4039(95)02069-1

M3 - Article

AN - SCOPUS:0030049828

SN - 0040-4039

VL - 37

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JO - Tetrahedron Letters

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IS - 1

ER -

Synthesis of 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine and its use as a probe to study DNA-base excision by mutY enzyme

Abstract

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