Synthesis of biologically active n2-amine adducts of 2'-deoxyguanosine

Radha R. Bonala; Irina G. Shishkina; Francis Johnson

doi:10.1016/S0040-4039(00)01196-5

Synthesis of biologically active n²-amine adducts of 2'-deoxyguanosine

Radha R. Bonala
, Irina G. Shishkina
, Francis Johnson

Pharmacological Sciences

Stony Brook University

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Several biologically important N²-adducts of 2’-deoxyguanosine (dG) that previously were difficultly accessible, have been synthesized directly by means of the Buchwald-Hartwig reaction. The reaction employed in each case involves the coupling of 2’-deoxy-2-bromoinosine with the appropriate amine. Deprotection in all cases gave good yields of the desired 2-alkylated or -arylated deoxynucleoside.

Original language	English
Pages (from-to)	7281-7284
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	38
DOIs	https://doi.org/10.1016/S0040-4039(00)01196-5
State	Published - Sep 16 2000

Keywords

2'-deoxyguanosine
Buchwald-Hartwig reaction
N-adducts

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10.1016/S0040-4039(00)01196-5

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title = "Synthesis of biologically active n2-amine adducts of 2'-deoxyguanosine",

abstract = "Several biologically important N2-adducts of 2{\textquoteright}-deoxyguanosine (dG) that previously were difficultly accessible, have been synthesized directly by means of the Buchwald-Hartwig reaction. The reaction employed in each case involves the coupling of 2{\textquoteright}-deoxy-2-bromoinosine with the appropriate amine. Deprotection in all cases gave good yields of the desired 2-alkylated or -arylated deoxynucleoside.",

keywords = "2'-deoxyguanosine, Buchwald-Hartwig reaction, N-adducts",

author = "Bonala, \{Radha R.\} and Shishkina, \{Irina G.\} and Francis Johnson",

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T1 - Synthesis of biologically active n2-amine adducts of 2'-deoxyguanosine

AU - Bonala, Radha R.

AU - Shishkina, Irina G.

AU - Johnson, Francis

PY - 2000/9/16

Y1 - 2000/9/16

N2 - Several biologically important N2-adducts of 2’-deoxyguanosine (dG) that previously were difficultly accessible, have been synthesized directly by means of the Buchwald-Hartwig reaction. The reaction employed in each case involves the coupling of 2’-deoxy-2-bromoinosine with the appropriate amine. Deprotection in all cases gave good yields of the desired 2-alkylated or -arylated deoxynucleoside.

AB - Several biologically important N2-adducts of 2’-deoxyguanosine (dG) that previously were difficultly accessible, have been synthesized directly by means of the Buchwald-Hartwig reaction. The reaction employed in each case involves the coupling of 2’-deoxy-2-bromoinosine with the appropriate amine. Deprotection in all cases gave good yields of the desired 2-alkylated or -arylated deoxynucleoside.

KW - 2'-deoxyguanosine

KW - Buchwald-Hartwig reaction

KW - N-adducts

UR - https://www.scopus.com/pages/publications/0034675293

U2 - 10.1016/S0040-4039(00)01196-5

DO - 10.1016/S0040-4039(00)01196-5

M3 - Article

AN - SCOPUS:0034675293

SN - 0040-4039

VL - 41

SP - 7281

EP - 7284

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -

Synthesis of biologically active n²-amine adducts of 2'-deoxyguanosine

Abstract

Keywords

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