Synthesis of chromophoric dipeptides as substrates for papain

J. D. Doran; P. J. Tonge; P. R. Carey; P. Arya

doi:10.1016/0960-894X(95)00415-P

Synthesis of chromophoric dipeptides as substrates for papain

J. D. Doran
, P. J. Tonge
, P. R. Carey
, P. Arya

Chemistry

Case Western Reserve University
National Research Council of Canada

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Chromophoric dipeptides (2) and (3) are found to be better substrates for papain in comparison to simpler substrates 1a or 1b. A synthetic strategy for obtaining α-NH(COOEt)-5-MTA-Et (1b), Ala-5-MTA-Et (2), Phe-5-MTA-Et (3) has been described.

Original language	English
Pages (from-to)	2381-2384
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	20
DOIs	https://doi.org/10.1016/0960-894X(95)00415-P
State	Published - Oct 19 1995

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title = "Synthesis of chromophoric dipeptides as substrates for papain",

abstract = "Chromophoric dipeptides (2) and (3) are found to be better substrates for papain in comparison to simpler substrates 1a or 1b. A synthetic strategy for obtaining α-NH(COOEt)-5-MTA-Et (1b), Ala-5-MTA-Et (2), Phe-5-MTA-Et (3) has been described.",

author = "Doran, \{J. D.\} and Tonge, \{P. J.\} and Carey, \{P. R.\} and P. Arya",

year = "1995",

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doi = "10.1016/0960-894X(95)00415-P",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Synthesis of chromophoric dipeptides as substrates for papain

AU - Doran, J. D.

AU - Tonge, P. J.

AU - Carey, P. R.

AU - Arya, P.

PY - 1995/10/19

Y1 - 1995/10/19

N2 - Chromophoric dipeptides (2) and (3) are found to be better substrates for papain in comparison to simpler substrates 1a or 1b. A synthetic strategy for obtaining α-NH(COOEt)-5-MTA-Et (1b), Ala-5-MTA-Et (2), Phe-5-MTA-Et (3) has been described.

AB - Chromophoric dipeptides (2) and (3) are found to be better substrates for papain in comparison to simpler substrates 1a or 1b. A synthetic strategy for obtaining α-NH(COOEt)-5-MTA-Et (1b), Ala-5-MTA-Et (2), Phe-5-MTA-Et (3) has been described.

UR - https://www.scopus.com/pages/publications/0028866550

U2 - 10.1016/0960-894X(95)00415-P

DO - 10.1016/0960-894X(95)00415-P

M3 - Article

AN - SCOPUS:0028866550

SN - 0960-894X

VL - 5

SP - 2381

EP - 2384

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 20

ER -

Synthesis of chromophoric dipeptides as substrates for papain

Abstract

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