Synthesis of Enkephalin analogs via asymmetric hydrogenation of dehydropeptide building blocks

Iwao Ojima; Noriko Yoda; Momoko Yatabe

doi:10.1016/S0040-4039(00)87742-4

Synthesis of Enkephalin analogs via asymmetric hydrogenation of dehydropeptide building blocks

Iwao Ojima
, Noriko Yoda
, Momoko Yatabe

Chemistry

Sagami Chemical Research Institute

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

[Ac-D-Tyr¹, D-Ala², Leu⁵-OMe]Enkephalin and [Ac-Tyr¹, D-Ala², Leu⁵-OMe]Enkephalin were successfully synthesized by the coupling of dipeptide units and tripeptide units which were readily obtained by the asymmetric hydrogenation of the corresponding dehydropeptide building blocks.

Original language	English
Pages (from-to)	3917-3920
Number of pages	4
Journal	Tetrahedron Letters
Volume	23
Issue number	38
DOIs	https://doi.org/10.1016/S0040-4039(00)87742-4
State	Published - 1982

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@article{3285b7f387ab444caa3068b352fb7a3a,

title = "Synthesis of Enkephalin analogs via asymmetric hydrogenation of dehydropeptide building blocks",

abstract = "[Ac-D-Tyr1, D-Ala2, Leu5-OMe]Enkephalin and [Ac-Tyr1, D-Ala2, Leu5-OMe]Enkephalin were successfully synthesized by the coupling of dipeptide units and tripeptide units which were readily obtained by the asymmetric hydrogenation of the corresponding dehydropeptide building blocks.",

author = "Iwao Ojima and Noriko Yoda and Momoko Yatabe",

year = "1982",

doi = "10.1016/S0040-4039(00)87742-4",

language = "English",

volume = "23",

pages = "3917--3920",

journal = "Tetrahedron Letters",

issn = "0040-4039",

number = "38",

}

TY - JOUR

T1 - Synthesis of Enkephalin analogs via asymmetric hydrogenation of dehydropeptide building blocks

AU - Ojima, Iwao

AU - Yoda, Noriko

AU - Yatabe, Momoko

PY - 1982

Y1 - 1982

N2 - [Ac-D-Tyr1, D-Ala2, Leu5-OMe]Enkephalin and [Ac-Tyr1, D-Ala2, Leu5-OMe]Enkephalin were successfully synthesized by the coupling of dipeptide units and tripeptide units which were readily obtained by the asymmetric hydrogenation of the corresponding dehydropeptide building blocks.

AB - [Ac-D-Tyr1, D-Ala2, Leu5-OMe]Enkephalin and [Ac-Tyr1, D-Ala2, Leu5-OMe]Enkephalin were successfully synthesized by the coupling of dipeptide units and tripeptide units which were readily obtained by the asymmetric hydrogenation of the corresponding dehydropeptide building blocks.

UR - https://www.scopus.com/pages/publications/49049137676

U2 - 10.1016/S0040-4039(00)87742-4

DO - 10.1016/S0040-4039(00)87742-4

M3 - Article

AN - SCOPUS:49049137676

SN - 0040-4039

VL - 23

SP - 3917

EP - 3920

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -

Synthesis of Enkephalin analogs via asymmetric hydrogenation of dehydropeptide building blocks

Abstract

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