Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines

Antonella Pepe; Michael Pamment; Gunda I. Georg; Sanjay V. Malhotra

doi:10.1021/jo102558u

Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines

Antonella Pepe
, Michael Pamment
, Gunda I. Georg
, Sanjay V. Malhotra

Chemistry

SAIC
University of Minnesota Twin Cities

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.

Original language	English
Pages (from-to)	3527-3530
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	76
Issue number	9
DOIs	https://doi.org/10.1021/jo102558u
State	Published - May 6 2011

Access to Document

10.1021/jo102558u

Cite this

@article{397fd55b74de4c9f859c14f28c895793,

title = "Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines",

abstract = "Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.",

author = "Antonella Pepe and Michael Pamment and Georg, \{Gunda I.\} and Malhotra, \{Sanjay V.\}",

year = "2011",

month = may,

day = "6",

doi = "10.1021/jo102558u",

language = "English",

volume = "76",

pages = "3527--3530",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

number = "9",

}

TY - JOUR

T1 - Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines

AU - Pepe, Antonella

AU - Pamment, Michael

AU - Georg, Gunda I.

AU - Malhotra, Sanjay V.

PY - 2011/5/6

Y1 - 2011/5/6

N2 - Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.

AB - Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.

UR - https://www.scopus.com/pages/publications/79955564974

U2 - 10.1021/jo102558u

DO - 10.1021/jo102558u

M3 - Article

C2 - 21452823

AN - SCOPUS:79955564974

SN - 0022-3263

VL - 76

SP - 3527

EP - 3530

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 9

ER -

Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines

Abstract

Access to Document

Other files and links

Fingerprint

Cite this