Synthesis of New Chiral Monodentate Phosphite Ligands and Their Use in Catalytic Asymmetric Hydrogenation

Zihao Hua; Victor C. Vassar; Iwao Ojima

doi:10.1021/ol035343r

Synthesis of New Chiral Monodentate Phosphite Ligands and Their Use in Catalytic Asymmetric Hydrogenation

Zihao Hua
, Victor C. Vassar
, Iwao Ojima

Chemistry

Stony Brook University

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

(Matrix presented) New monodentate phosphite ligands have been developed from axially chiral biphenols, which show excellent enantioselectivity in the Rh-(I)-catalyzed hydrogenation of dimethyl itaconate. The new chiral ligand system is suitable to create libraries and possesses fine-tuning capability.

Original language	English
Pages (from-to)	3831-3834
Number of pages	4
Journal	Organic Letters
Volume	5
Issue number	21
DOIs	https://doi.org/10.1021/ol035343r
State	Published - Oct 16 2003

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title = "Synthesis of New Chiral Monodentate Phosphite Ligands and Their Use in Catalytic Asymmetric Hydrogenation",

abstract = "(Matrix presented) New monodentate phosphite ligands have been developed from axially chiral biphenols, which show excellent enantioselectivity in the Rh-(I)-catalyzed hydrogenation of dimethyl itaconate. The new chiral ligand system is suitable to create libraries and possesses fine-tuning capability.",

author = "Zihao Hua and Vassar, \{Victor C.\} and Iwao Ojima",

year = "2003",

month = oct,

day = "16",

doi = "10.1021/ol035343r",

language = "English",

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journal = "Organic Letters",

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T1 - Synthesis of New Chiral Monodentate Phosphite Ligands and Their Use in Catalytic Asymmetric Hydrogenation

AU - Hua, Zihao

AU - Vassar, Victor C.

AU - Ojima, Iwao

PY - 2003/10/16

Y1 - 2003/10/16

N2 - (Matrix presented) New monodentate phosphite ligands have been developed from axially chiral biphenols, which show excellent enantioselectivity in the Rh-(I)-catalyzed hydrogenation of dimethyl itaconate. The new chiral ligand system is suitable to create libraries and possesses fine-tuning capability.

AB - (Matrix presented) New monodentate phosphite ligands have been developed from axially chiral biphenols, which show excellent enantioselectivity in the Rh-(I)-catalyzed hydrogenation of dimethyl itaconate. The new chiral ligand system is suitable to create libraries and possesses fine-tuning capability.

UR - https://www.scopus.com/pages/publications/0242460334

U2 - 10.1021/ol035343r

DO - 10.1021/ol035343r

M3 - Article

C2 - 14535721

AN - SCOPUS:0242460334

SN - 1523-7060

VL - 5

SP - 3831

EP - 3834

JO - Organic Letters

JF - Organic Letters

IS - 21

ER -

Synthesis of New Chiral Monodentate Phosphite Ligands and Their Use in Catalytic Asymmetric Hydrogenation

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